Publication Date:
1978-06-09
Description:
Intracaudate injections of kainic acid destroy striatal neurons containing acetylcholine and gamma-aminobutyric acid but leave dopaminergic nerve terminals in this brain region intact. Rats injected with the drug are aphagic and adipsic, and have other behavioral abnormalities strikingly similar to those seen in animals with lesions in the dopaminergic nigrostriatal bundle.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pettibone, D J -- Kaufman, N -- Scally, M C -- Meyer, E Jr -- Ulus, I -- Lytle, L D -- New York, N.Y. -- Science. 1978 Jun 9;200(4346):1175-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/653362" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Behavior, Animal/drug effects
;
Caudate Nucleus/*drug effects/physiology
;
Choline O-Acetyltransferase/metabolism
;
Dopamine/metabolism
;
Dose-Response Relationship, Drug
;
Drinking Behavior/*drug effects
;
Feeding Behavior/*drug effects
;
Glutamate Decarboxylase/metabolism
;
Kainic Acid/*pharmacology
;
Male
;
Posture
;
Pyrrolidines/*pharmacology
;
Rats
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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