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    Innate immune homeostasis by the homeobox gene caudal and commensal-gut mutualism in Drosophila (2008)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2008-01-26
    Description: Although commensalism with gut microbiota exists in all metazoans, the host factors that maintain this homeostatic relationship remain largely unknown. We show that the intestinal homeobox gene Caudal regulates the commensal-gut mutualism by repressing nuclear factor kappa B-dependent antimicrobial peptide genes. Inhibition of Caudal expression in flies via RNA interference led to overexpression of antimicrobial peptides, which in turn altered the commensal population within the intestine. In particular, the dominance of one gut microbe, Gluconobacter sp. strain EW707, eventually led to gut cell apoptosis and host mortality. However, restoration of a healthy microbiota community and normal host survival in the Caudal-RNAi flies was achieved by reintroduction of the Caudal gene. These results reveal that a specific genetic deficiency within a host can profoundly influence the gut commensal microbial community and host physiology.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ryu, Ji-Hwan -- Kim, Sung-Hee -- Lee, Hyo-Young -- Bai, Jin Young -- Nam, Young-Do -- Bae, Jin-Woo -- Lee, Dong Gun -- Shin, Seung Chul -- Ha, Eun-Mi -- Lee, Won-Jae -- New York, N.Y. -- Science. 2008 Feb 8;319(5864):777-82. doi: 10.1126/science.1149357. Epub 2008 Jan 24.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Molecular Life Science, Ewha Woman's University and National Creative Research Initiative Center for Symbiosystem, Seoul 120-750, South Korea.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18218863" target="_blank"〉PubMed〈/a〉
    Keywords: Acetobacteraceae/growth & development ; Animals ; Animals, Genetically Modified ; Antibiosis ; Antimicrobial Cationic Peptides/biosynthesis/genetics ; Apoptosis ; Bacteria/growth & development ; Drosophila Proteins/*genetics/metabolism/physiology ; Drosophila melanogaster/genetics/*immunology/metabolism/*microbiology ; Epithelial Cells/cytology/metabolism ; Gene Expression Regulation ; *Genes, Homeobox ; Genes, Insect ; Germ-Free Life ; Gluconobacter/*growth & development/pathogenicity ; Homeodomain Proteins/*genetics/physiology ; Homeostasis ; *Immunity, Innate ; Intestines/cytology/immunology/metabolism/microbiology ; RNA Interference ; Symbiosis ; Transcription Factors/*genetics/metabolism/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    A direct role for dual oxidase in Drosophila gut immunity (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-11-08
    Description: Because the mucosal epithelia are in constant contact with large numbers of microorganisms, these surfaces must be armed with efficient microbial control systems. Here, we show that the Drosophila nicotinamide adenine dinucleotide phosphate (NADPH) oxidase enzyme, dual oxidase (dDuox), is indispensable for gut antimicrobial activities. Adult flies in which dDuox expression is silenced showed a marked increase in mortality rate even after a minor infection through ingestion of microbe-contaminated food. This could be restored by the specific reintroduction of dDuox, demonstrating that this oxidase generates a unique epithelial oxidative burst that limits microbial proliferation in the gut. Thus, oxidant-mediated antimicrobial responses are not restricted to the phagocytes, but rather are used more broadly, including in mucosal barrier epithelia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ha, Eun-Mi -- Oh, Chun-Taek -- Bae, Yun Soo -- Lee, Won-Jae -- New York, N.Y. -- Science. 2005 Nov 4;310(5749):847-50.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Molecular Life Science and Center for Cell Signaling Research, Ewha Woman's University, Seoul 120-750, South Korea.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16272120" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Genetically Modified ; Bacteria/*growth & development/immunology ; Catalase/genetics/metabolism ; Chlorides/metabolism ; Colony Count, Microbial ; Digestive System/enzymology/immunology/microbiology ; Drosophila/*enzymology/*immunology/microbiology ; *Immunity, Innate ; In Vitro Techniques ; Intestinal Mucosa/enzymology/immunology/microbiology ; NADPH Oxidase/genetics/*metabolism ; RNA Interference ; Reactive Oxygen Species/metabolism ; Respiratory Burst ; Saccharomyces cerevisiae/*growth & development/immunology ; Superoxides/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
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