Publication Date:
2002-04-27
Description:
Lymphatic metastasis contributes to mortality from solid tumors. Whether metastasizing cancer cells reach lymph nodes via intratumor lymphatic vessels is unknown. Here, we examine functional lymphatics associated with mouse tumors expressing normal or elevated levels of vascular endothelial growth factor-C (VEGF-C), a molecule that stimulates lymphangiogenesis. Although VEGF-C overexpression increased lymphatic surface area in the tumor margin and lymphatic metastasis, these tumors contained no functional lymphatics, as assessed by four independent functional assays and immunohistochemical staining. These findings suggest that the functional lymphatics in the tumor margin alone are sufficient for lymphatic metastasis and should be targeted therapeutically.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Padera, Timothy P -- Kadambi, Ananth -- di Tomaso, Emmanuelle -- Carreira, Carla Mouta -- Brown, Edward B -- Boucher, Yves -- Choi, Noah C -- Mathisen, Douglas -- Wain, John -- Mark, Eugene J -- Munn, Lance L -- Jain, Rakesh K -- R24-CA85140/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2002 Jun 7;296(5574):1883-6. Epub 2002 Apr 25.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉E. L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, 100 Blossom Street, Boston, MA 02114, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11976409" target="_blank"〉PubMed〈/a〉
Keywords:
Adenocarcinoma/chemistry/pathology
;
Animals
;
Antigens, Surface/analysis
;
Endothelial Growth Factors/metabolism
;
Extracellular Space/physiology
;
Fibrosarcoma/metabolism/*pathology/physiopathology/secondary
;
Glycoproteins/analysis
;
Humans
;
Immunohistochemistry
;
Lung Neoplasms/chemistry/pathology/physiopathology/secondary
;
*Lymphatic Metastasis
;
Lymphatic System/chemistry/*pathology/physiology
;
Lymphography
;
Melanoma, Experimental/metabolism/*pathology/physiopathology/secondary
;
Mice
;
Mice, Inbred C3H
;
Mice, Nude
;
Microscopy/methods
;
Neoplasm Transplantation
;
Neoplasms/metabolism/*pathology/physiopathology
;
Pressure
;
Tumor Cells, Cultured
;
Vascular Endothelial Growth Factor C
;
Vesicular Transport Proteins
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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