Publication Date:
1979-09-28
Description:
In the brains of deceased schizophrenics who underwent long-term treatment with antipsychotic drugs, the concentration of homovanillic acid (a dopamine metabolite) was significantly increased in the orbital frontal, cingulate, and temporal tip areas of the cortex, but not in the putamen or the nucleus accumbens. The concentration of homovanillic acid was normal in the brains of schizophrenics who were not treated with drugs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bacopoulos, N C -- Spokes, E G -- Bird, E D -- Roth, R H -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1405-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/38504" target="_blank"〉PubMed〈/a〉
Keywords:
3,4-Dihydroxyphenylacetic Acid/metabolism
;
Antipsychotic Agents/therapeutic use
;
Brain/*metabolism
;
Cerebral Cortex/metabolism
;
Dopamine/*metabolism
;
Homovanillic Acid/metabolism
;
Humans
;
Nucleus Accumbens/metabolism
;
Putamen/metabolism
;
Schizophrenia/*drug therapy/metabolism
;
Time Factors
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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