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  • 1
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    Whole-genome patterns of common DNA variation in three human populations (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-02-19
    Description: Individual differences in DNA sequence are the genetic basis of human variability. We have characterized whole-genome patterns of common human DNA variation by genotyping 1,586,383 single-nucleotide polymorphisms (SNPs) in 71 Americans of European, African, and Asian ancestry. Our results indicate that these SNPs capture most common genetic variation as a result of linkage disequilibrium, the correlation among common SNP alleles. We observe a strong correlation between extended regions of linkage disequilibrium and functional genomic elements. Our data provide a tool for exploring many questions that remain regarding the causal role of common human DNA variation in complex human traits and for investigating the nature of genetic variation within and between human populations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hinds, David A -- Stuve, Laura L -- Nilsen, Geoffrey B -- Halperin, Eran -- Eskin, Eleazar -- Ballinger, Dennis G -- Frazer, Kelly A -- Cox, David R -- New York, N.Y. -- Science. 2005 Feb 18;307(5712):1072-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Perlegen Sciences Inc., 2021 Stierlin Court, Mountain View, CA 94043, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15718463" target="_blank"〉PubMed〈/a〉
    Keywords: African Americans/*genetics ; Algorithms ; Asian Continental Ancestry Group/*genetics ; Case-Control Studies ; Chromosome Mapping ; Databases, Genetic ; European Continental Ancestry Group/*genetics ; Female ; Gene Frequency ; Genetic Markers ; Genetic Predisposition to Disease ; *Genetic Variation ; *Genome, Human ; Genotype ; Haplotypes ; Humans ; Linkage Disequilibrium ; Male ; Multifactorial Inheritance ; *Polymorphism, Single Nucleotide ; Recombination, Genetic ; Risk Factors ; Selection, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Mouse genomic variation and its effect on phenotypes and gene regulation (2011)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2011-09-17
    Description: We report genome sequences of 17 inbred strains of laboratory mice and identify almost ten times more variants than previously known. We use these genomes to explore the phylogenetic history of the laboratory mouse and to examine the functional consequences of allele-specific variation on transcript abundance, revealing that at least 12% of transcripts show a significant tissue-specific expression bias. By identifying candidate functional variants at 718 quantitative trait loci we show that the molecular nature of functional variants and their position relative to genes vary according to the effect size of the locus. These sequences provide a starting point for a new era in the functional analysis of a key model organism.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276836/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276836/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Keane, Thomas M -- Goodstadt, Leo -- Danecek, Petr -- White, Michael A -- Wong, Kim -- Yalcin, Binnaz -- Heger, Andreas -- Agam, Avigail -- Slater, Guy -- Goodson, Martin -- Furlotte, Nicholas A -- Eskin, Eleazar -- Nellaker, Christoffer -- Whitley, Helen -- Cleak, James -- Janowitz, Deborah -- Hernandez-Pliego, Polinka -- Edwards, Andrew -- Belgard, T Grant -- Oliver, Peter L -- McIntyre, Rebecca E -- Bhomra, Amarjit -- Nicod, Jerome -- Gan, Xiangchao -- Yuan, Wei -- van der Weyden, Louise -- Steward, Charles A -- Bala, Sendu -- Stalker, Jim -- Mott, Richard -- Durbin, Richard -- Jackson, Ian J -- Czechanski, Anne -- Guerra-Assuncao, Jose Afonso -- Donahue, Leah Rae -- Reinholdt, Laura G -- Payseur, Bret A -- Ponting, Chris P -- Birney, Ewan -- Flint, Jonathan -- Adams, David J -- 077192/Wellcome Trust/United Kingdom -- 079912/Wellcome Trust/United Kingdom -- 082356/Wellcome Trust/United Kingdom -- 083573/Wellcome Trust/United Kingdom -- 083573/Z/07/Z/Wellcome Trust/United Kingdom -- 085906/Wellcome Trust/United Kingdom -- 085906/Z/08/Z/Wellcome Trust/United Kingdom -- 090532/Wellcome Trust/United Kingdom -- 2T15LM007359/LM/NLM NIH HHS/ -- A6997/Cancer Research UK/United Kingdom -- BB/F022697/1/Biotechnology and Biological Sciences Research Council/United Kingdom -- G0800024/Medical Research Council/United Kingdom -- K25 HL080079/HL/NHLBI NIH HHS/ -- MC_U127561112/Medical Research Council/United Kingdom -- MC_U137761446/Medical Research Council/United Kingdom -- Cancer Research UK/United Kingdom -- Medical Research Council/United Kingdom -- England -- Nature. 2011 Sep 14;477(7364):289-94. doi: 10.1038/nature10413.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21921910" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Animals ; Animals, Laboratory/genetics ; Gene Expression Regulation/*genetics ; Genetic Variation/*genetics ; Genome/*genetics ; Genomics ; Mice/classification/*genetics ; Mice, Inbred C57BL/genetics ; Mice, Inbred Strains/*genetics ; *Phenotype ; Phylogeny ; Quantitative Trait Loci/genetics
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 3
    Electronic Resource
    Electronic Resource
    Predicting the profile of glass strip and other sheet materials with an adaptation (1976)
    Springer
    Glass and ceramics 33 (1976), S. 692-696 
    Details
    ISSN: 1573-8515
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00700478
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  • 4
    Electronic Resource
    Electronic Resource
    Changes in the physicomechanical properties of fabric glass laminate upon repeated thermal loading (1978)
    Springer
    Strength of materials 10 (1978), S. 340-344 
    Details
    ISSN: 1573-9325
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Conclusions 1. Cyclic thermal loading reveals a complex dependence of the physicomechanical properties of fabric glass laminate on the number of cycles. At temperatures of up to 400°C the main changes in the state of the material, reflected in its strength, occur in the first two heating cycles. 2. For stress analysis of structures made of polymer-based composite materials and operating under conditions of repeated thermal loading, the results obtained after a single heating cannot be used. To obtain a more accurate picture of the strength potential of such materials, their physicomechanical properties have to be investigated by modeling the operating conditions of the structure (number of cycles, cycle temperature, heating rate, etc.). 3. In assessing the effect of the repetition of thermal loading on the physicomechanical properties of composite polymer materials, their properties should be evaluated both at normal temperatures between cycles and at the cycle temperatures, so as to obtain the minimum values of the investigated properties (strength, modulus of elasticity). 4. Up to 400°C and ten thermal loading cycles the investigated material retains sufficient strength (up to 40% of the initial value), and it may therefore be recommended for use under corresponding thermal loading.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01522757
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  • 5
    Electronic Resource
    Electronic Resource
    Strength and features of fracture of fiberglass-reinforced plastics in the 77–400 K temperature range (1988)
    Springer
    Strength of materials 20 (1988), S. 1102-1106 
    Details
    ISSN: 1573-9325
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Conclusion 1. The strength and elastic characteristics of fiberglass laminate with a silicone binder were determined and the rules of their change under single and repeated temperature action were established. 2. It was shown that in tension and compression in the 77–400 K temperature range fracture of the material occurs both as the result of development of microcracks existing in the original structure of the material and preferentially oriented in planes perpendicular to the plane of the reinforcing fabric and as the result of development of defects at the interface of the components in the planes of reinforcing. 3. It was established that with a reduction in temperature the contribution to the fracture process of defects (cracks) developing at the interface of the components increases, as the result of which under low temperature conditions fracture of the material both in tension and in compression is initiated by separation of it.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01528687
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  • 6
    Electronic Resource
    Electronic Resource
    Device for studying the strength and rigidity of round plates of anisotropic material (1972)
    Springer
    Strength of materials 4 (1972), S. 1391-1393 
    Details
    ISSN: 1573-9325
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01527813
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  • 7
    Electronic Resource
    Electronic Resource
    Temperature deformation coefficients on rotation of the coordinate axes in anisotropic bodies (1974)
    Springer
    Strength of materials 6 (1974), S. 56-59 
    Details
    ISSN: 1573-9325
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Conclusions 1. Expressions have been obtained for transforming the temperature deformation coefficients under a rotation of axes. 2. It has been shown that for orthotropic materials the generalized Hooke's law expressions written in the principal axes of elastic symmetry (1) do not contain the shear coefficient of temperature deformation; these coefficients do however appear if the coordinate axes are rotated. 3. It has been shown that the graphical construction of the expressions for the transformation of the temperature coefficients is similar to that for the transformation of components of the stress or strain tensors. 4. The curve for the shear coefficient of the temperature deformation takes the particular form of a Cassini oval (lemniscate) which is symmetrical about a straight line making an angle of 45° with the elastic symmetry axes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01528161
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  • 8
    Electronic Resource
    Electronic Resource
    Method of determining thermal strains in composite polymer materials (1976)
    Springer
    Strength of materials 8 (1976), S. 1475-1479 
    Details
    ISSN: 1573-9325
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Conclusions 1. Asbotextolite VTU UKh P 183-60 has a considerable anisotropy of its thermal strains along the axes of elastic symmetry; this must be taken into account when designing structural elements of these materials. Glass Textolite SSFT has a more equally balanced arrangement of the fabric pattern and a more uniform distribution of its filaments with respect to direction; it accordingly has a lower anisotropy of its thermal strains. 2. There are considerable differences between the quantitative estimates of the thermal strains in these materials determined by means of rod and disk samples, respectively, especially in the directions deviating from the axes of elastic symmetry. 3. The method of measuring thermal strains on round (disk) samples may be recommended as more correct, since it eliminates the effects of the severed filaments and also enables shear strains to be measured. 4. A study of the shrinkage of Asbotextolite shows that the latter possesses shrinkage anisotropy of the same character as the anisotropy of the thermal strains. In addition to this, the shrinkage of Asbotextolite is closely related to the loss of weight by this material.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01528362
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  • 9
    Electronic Resource
    Electronic Resource
    Effect of temperature on the physicomechanical characteristics of carbon-plastics (1980)
    Springer
    Strength of materials 12 (1980), S. 861-865 
    Details
    ISSN: 1573-9325
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Conclusions 1. The character of the change in the mechanical characteristics of carbon-metal-plastics with heating was shown. It was noted that strength and elastic modulus change more rapidly in compression and bending than in tension. 2. Strain-hardening of carbon-plastic and carbon-metal-plastic was observed in compression within the temperature interval 200–400 °C. 3. It was demonstrated that it is possible to approximate the stress-strain diagram of orthotropic materials with an equation of the form ɛ = σ/E [ 1 + k/n (σ/σp. 1.) n−1], the applicability of which was confirmed by the empirical data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00767474
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  • 10
    Electronic Resource
    Electronic Resource
    Anisotropy of the physicomechanical characteristics of asbestos, glass, and carbon textolites in the 293-873°K temperature range (1982)
    Springer
    Strength of materials 14 (1982), S. 984-989 
    Details
    ISSN: 1573-9325
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Conclusions 1. The investigated materials possess significant anisotropy of mechanical properties in tension and bending and insignificant in compression. With an increase in temperature the parameters of anisotropy increase, especially in carbon and carbon-metal plastics. 2. The relationships of tensile strength and modulus of elasticity of the studied materials to the angle of the test α have the form of steadily dropping curves which with an increase in temperature do not change substantially.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01126253
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