Publication Date:
2010-05-08
Description:
Obesity results from chronic energy surplus and excess lipid storage in white adipose tissue (WAT). In contrast, brown adipose tissue (BAT) efficiently burns lipids through adaptive thermogenesis. Studying mouse models, we show that cyclooxygenase (COX)-2, a rate-limiting enzyme in prostaglandin (PG) synthesis, is a downstream effector of beta-adrenergic signaling in WAT and is required for the induction of BAT in WAT depots. PG shifted the differentiation of defined mesenchymal progenitors toward a brown adipocyte phenotype. Overexpression of COX-2 in WAT induced de novo BAT recruitment in WAT, increased systemic energy expenditure, and protected mice against high-fat diet-induced obesity. Thus, COX-2 appears integral to de novo BAT recruitment, which suggests that the PG pathway regulates systemic energy homeostasis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vegiopoulos, Alexandros -- Muller-Decker, Karin -- Strzoda, Daniela -- Schmitt, Iris -- Chichelnitskiy, Evgeny -- Ostertag, Anke -- Berriel Diaz, Mauricio -- Rozman, Jan -- Hrabe de Angelis, Martin -- Nusing, Rolf M -- Meyer, Carola W -- Wahli, Walter -- Klingenspor, Martin -- Herzig, Stephan -- New York, N.Y. -- Science. 2010 May 28;328(5982):1158-61. doi: 10.1126/science.1186034. Epub 2010 May 6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Emmy Noether and Marie Curie Research Group Molecular Metabolic Control, German Cancer Research Center (DKFZ) Heidelberg, 69120 Heidelberg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20448152" target="_blank"〉PubMed〈/a〉
Keywords:
Adipocytes, Brown/cytology/*physiology
;
Adipogenesis
;
Adipose Tissue
;
Adipose Tissue, Brown/cytology/*physiology
;
Adipose Tissue, White/enzymology/*physiology
;
Adrenergic beta-3 Receptor Agonists
;
Adrenergic beta-Agonists/pharmacology
;
Animals
;
Body Weight
;
Cyclooxygenase 2/*genetics/*metabolism
;
Dietary Fats/administration & dosage
;
Dioxoles/pharmacology
;
*Energy Metabolism
;
Female
;
Gene Expression Regulation, Enzymologic
;
Homeostasis
;
Male
;
Mesenchymal Stromal Cells/cytology
;
Mice
;
Mice, Inbred C57BL
;
Mice, Obese
;
Mice, Transgenic
;
Norepinephrine/metabolism
;
Obesity/etiology/prevention & control
;
Oxygen Consumption
;
Prostaglandins/*metabolism
;
Receptors, Adrenergic, beta-3/metabolism
;
Signal Transduction
;
*Thermogenesis
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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