ISSN:
1573-4986
Keywords:
N-acetyl neuraminic acid
;
lectin
;
glycosynthon
;
oligosaccharide
;
sialic acid
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Neoglycoconjugates are useful tools to study carbohydrate/protein interactions. In order to discover new lectins, to define their fine specificity or to study their intracellular trafficking, there is a need for neoglycoconjugates containing complex oligosaccharides. We recently set up a simple way to transform native oligosaccharides into glycosynthons. The present paper describes i[emsp4 ]) the synthesis of such glycosynthons starting with sialylated oligosides, ii[emsp4 ]) the preparation of sialylated neoglycoproteins and iii[emsp4 ]) their binding to sialic acid-specific lectins assessed by surface plasmon resonance experiments.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1007131931851
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