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  • 1
    Publication Date: 2019
    Description: Plk1 inhibition compromises kinetochore integrity during chromosome segregation without activating mitotic checkpoint, thereby leading to formation of micronuclei. Abstract During mitosis, sister chromatids attach to microtubules which generate ~ 700 pN pulling force focused on the centromere. We report that chromatin‐localized signals generated by Polo‐like kinase 1 (Plk1) maintain the integrity of the kinetochore and centromere against this force. Without sufficient Plk1 activity, chromosomes become misaligned after normal condensation and congression. These chromosomes are silent to the mitotic checkpoint, and many lag and mis‐segregate in anaphase. Their centromeres and kinetochores lack CENP‐A, CENP‐C, CENP‐T, Hec1, Nuf2, and Knl1; however, CENP‐B is retained. CENP‐A loss occurs coincident with secondary misalignment and anaphase onset. This disruption occurs asymmetrically prior to anaphase and requires tension generated by microtubules. Mechanistically, centromeres highly recruit PICH DNA helicase and PICH depletion restores kinetochore disruption in pre‐anaphase cells. Furthermore, anaphase defects are significantly reduced by tethering Plk1 to chromatin, including H2B, and INCENP, but not to CENP‐A. Taken as a whole, this demonstrates that Plk1 signals are crucial for stabilizing centromeric architecture against tension.
    Print ISSN: 1469-221X
    Electronic ISSN: 1469-3178
    Topics: Biology , Medicine
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  • 2
    Publication Date: 2007-09-01
    Print ISSN: 1570-9639
    Electronic ISSN: 1878-1454
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Published by Elsevier
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  • 3
    Publication Date: 2024-04-08
    Description: Over the recent decades, the possibilities to surveil people have increased and been refined with the ongoing digital transformation of society. Surveillance can now go in any direction, and various forms of online surveillance saturate most people’s lives, which are increasingly lived in digital environments. To understand this situation and nuance the contemporary discussions about surveillance – not least in the highly digitalised context of the Nordic countries – we must adopt cultural and ethical perspectives in studying people’s attitudes, motives, and behaviours. The “culture of surveillance”, to borrow David Lyon’s term, is a culture where questions about privacy and publicness, and rights and benefits, are once again brought to the fore. This anthology takes up this challenge, with contributions from a variety of disciplinary and theoretical frameworks that discuss and shed light on the complexity of contemporary surveillance and thus problematise power relations between the many actors involved in the development and performance of surveillance culture. The contributions highlight how more and more actors and practices play a part in our increasingly digitalised society. The book is an outcome of the research project “iAccept: Soft surveillance – between acceptance and resistance”, financed by the Marcus and Amalia Wallenberg Foundation. The anthology’s editors are project members, all based at Umeå University, Sweden: Lars Samuelsson, associate professor of philosophy; Coppélie Cocq, professor of Sámi studies and digital humanities; Stefan Gelfgren, associate professor of sociology of religion; and Jesper Enbom, associate professor of media studies.
    Description: Published
    Description: Over the recent decades, the possibilities to surveil people have increased and been refined with the ongoing digital transformation of society. Surveillance can now go in any direction, and various forms of online surveillance saturate most people’s lives, which are increasingly lived in digital environments. To understand this situation and nuance the contemporary discussions about surveillance – not least in the highly digitalised context of the Nordic countries – we must adopt cultural and ethical perspectives in studying people’s attitudes, motives, and behaviours. The “culture of surveillance”, to borrow David Lyon’s term, is a culture where questions about privacy and publicness, and rights and benefits, are once again brought to the fore. This anthology takes up this challenge, with contributions from a variety of disciplinary and theoretical frameworks that discuss and shed light on the complexity of contemporary surveillance and thus problematise power relations between the many actors involved in the development and performance of surveillance culture. The contributions highlight how more and more actors and practices play a part in our increasingly digitalised society. The book is an outcome of the research project “iAccept: Soft surveillance – between acceptance and resistance”, financed by the Marcus and Amalia Wallenberg Foundation. The anthology’s editors are project members, all based at Umeå University, Sweden: Lars Samuelsson, associate professor of philosophy; Coppélie Cocq, professor of Sámi studies and digital humanities; Stefan Gelfgren, associate professor of sociology of religion; and Jesper Enbom, associate professor of media studies.
    Keywords: surveillance culture ; online surveillance ; digital transformation ; ethics of surveillance ; digital humanities ; surveillance ; digitalisation ; data-driven ; bic Book Industry Communication::H Humanities::HP Philosophy::HPS Social & political philosophy ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFM Ethical issues & debates::JFMG Ethical issues: scientific & technological developments ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDT Topics in philosophy::QDTS Social and political philosophy ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBF Social and ethical issues::JBFV Ethical issues and debates::JBFV5 Ethical issues: scientific, technological and medical developments
    Language: English
    Format: application/pdf
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