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  • 1
    Electronic Resource
    Electronic Resource
    Bioactive polymers XXI. Coupling of chloramphenicol on Biozan R (1985)
    Springer
    Colloid & polymer science 263 (1985), S. 620-623 
    Details
    ISSN: 1435-1536
    Keywords: Biozan R ; chloramphenicol ; coupling ; antimicrobial activity ; dicyclohexylcarbodiimide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The coupling of chloramphenicol on Biozan R (Hercules) by activation with dicyclohexylcarbodiimide was studied. The esterification is influenced by the chloramphenicol/dicyclohexylcarbodiimide ratio, concentration of the reactants and reaction time. The microbial tests performed with products of different chloramphenicol contents attest their antimicrobial activity and their possible use, especially in ophtalmology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01419885
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  • 2
    Electronic Resource
    Electronic Resource
    XV. Hydrolases immobilized on Biozan R (1984)
    Springer
    Colloid & polymer science 262 (1984), S. 705-711 
    Details
    ISSN: 1435-1536
    Keywords: Bioactive polymers ; Biozan R ; Immobilized enzymes ; Invertase ; Amyloglucosidase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract In the present paper the immobilization of invertase and amyloglucosidase on Biozan R with dicyclohexylcarbodiimide as a catalyst is studied. The influence of some factors on the coupling reaction (duration, enzyme/support and catalyst/support ratios) as well on the acitvity of the coupled enzyme in followed. For both systems under study the value of the Michaelis-Menten constant is higher for the coupled enzyme than for the free one.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01451542
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  • 3
    Electronic Resource
    Electronic Resource
    Thermal analysis methods in the study op some retard macromolbcular drugs
    Amsterdam : Elsevier
    Thermochimica Acta 134 (1988), S. 167-175 
    Details
    ISSN: 0040-6031
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0040-6031(88)85233-X
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  • 4
    Electronic Resource
    Electronic Resource
    Bioactive polymers 67: isosorbide dinitrate retardation in xanthan-based hydrogels (1991)
    Springer
    Colloid & polymer science 269 (1991), S. 1140-1147 
    Details
    ISSN: 1435-1536
    Keywords: Hydrogel ; reticulatedxanthan ; isosorbidedinitrateretardation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Xanthan and its crosslinked beads have many biomedical applications. Xanthan has been reticulated with epichlorohydrin, thus becoming a hydrogel with a swelling ratio in the range 1–10 and having a solvent content of 80–90%. Through its diffusion from alcohol/water mixture (5/1–5/4,v/v) of various concentrations, isosorbide dinitrate has been inserted into the hydrogel. The content of isosorbide dinitrate in the hydrogel varies in the range 40–150 mg/g. The drug is released according to “zero-order” kinetics at a constant rate of 1.5 μg/h, for a duration of 9 h.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00654122
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  • 5
    Electronic Resource
    Electronic Resource
    Bioactive polymers 61. synthesis and characterization of some retard antibiotics (1989)
    Springer
    Colloid & polymer science 267 (1989), S. 595-599 
    Details
    ISSN: 1435-1536
    Keywords: Ampicillin (I) ; chloramphenicol (II) ; xanthan ; dicyclohexyl-carbodiimide ; drugrelease ; invitro (for I) ; invitro and invivo (for II)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Ampicillin and chloramphenicol were coupled on xanthan by activation by dicyclohexyl-carbodiimide. Drug release from the support was studied in vitro for ampicillin, and in vitro and in vivo conditions for chloramphenicol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01410436
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  • 6
    Electronic Resource
    Electronic Resource
    New polyimidazolyl and pyrazolyl esters (1980)
    Springer
    Polymer bulletin 2 (1980), S. 565-570 
    Details
    ISSN: 1436-2449
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Summary New polyimidazolyl and polypyrazolyl esters were synthesized by polycondensation of the chlorides of the pyrazolyl and imidazolyl dicarboxylic acids with ethylene glycol,pentamethylene glycol and glycerol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00255260
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  • 7
    Electronic Resource
    Electronic Resource
    Bifunctional initiators (1980)
    Springer
    Polymer bulletin 3 (1980), S. 363-368 
    Details
    ISSN: 1436-2449
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Summary Poly(methylmethacrylate-b-styrene) and poly(methylmetha-crylate-b-acrylonitrile) block copolymers are synthesized by means of the 4,4′-azo-bis-(4-cynovaleryl)-benzoyldiperoxide. In the first stage a polymethylme-thacrylate prepolymer is synthesized using the above mentioned initiator.The prepolymer containing peroxide end groups is employed in the second stage for the block copolymerization of styrene or acrylonitrile.The block copolymer structure was elucidated by means of IR and NMR spectral measurements.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00255096
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  • 8
    Electronic Resource
    Electronic Resource
    Copolymerization of acryloyl chloride with 2-hydroxypropyl methacrylate (1983)
    Weinheim : Wiley-Blackwell
    Acta Polymerica 34 (1983), S. 60-61 
    Details
    ISSN: 0323-7648
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/actp.1983.010340112
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  • 9
    Electronic Resource
    Electronic Resource
    Kinetics of the condensation reaction of carboxylated polymers activated by dicyclohexylcarbodiimide (1989)
    Weinheim : Wiley-Blackwell
    Acta Polymerica 40 (1989), S. 233-235 
    Details
    ISSN: 0323-7648
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Die Kinetik der Kondensationsreaktion zwischen 2-Aminopropan und zwei mit Dicyclohcxylcarbodiimid aktivierten, Carboxylgruppen enthaltenden Polymeren (Polyacrylsaure und Xanthan) wurde untersucht. Die Geschwindigkeitskonstanten der Reaktion zweiter Ordnung wurden bestimmt und diskutiert.
    Notes: Kinetical studies were performed on the condensation reactions of 2-aminopropane and two carboxylated polymers (poly(acrylic acid) and xanthan) in the presence of dicyclohexylcarbodiimide as an activator. The rate constants of the second order reactions were determined and discussed.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/actp.1989.010400403
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  • 10
    Electronic Resource
    Electronic Resource
    Enzymes and drugs immobilized on polymers. Synthesis and application in therapeutics (1987)
    Weinheim : Wiley-Blackwell
    Acta Polymerica 38 (1987), S. 145-148 
    Details
    ISSN: 0323-7648
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Verschiedene Enzyme (α-Amylase, Amyloglucosidase) und Arzneistoffe (Procain, 7-Amino-Cephalosporansäure, Sulfatiasol, Ampicillin, Chloramphenicol) wurden covalent an Cellulosederivate und Biozan R gebunden, um biologisch aktive Verbindungen zu erhalten. Die Kopplungsreaktion wurde unter Verwendung von Dicyclohexylcarbodiimid als Aktivator durchgeführtß. Die optimalen Werte der Reaktionsparameter (Temperatur, Zeit, Konzentration der Arzneistoffe, Trägermenge, Aktivatorkonzentration) wurden bestimmt.
    Notes: Different enzymes (α-amylase, amyloglucosidase) and drugs (procaine, 7-aminocephalosporanic acid, sulphathiazole, ampicillin, chloramphenicol) have been immobilized on cellulose derivatives and Biozan R through covalent bonds to obtain biologically active compounds. Coupling reaction of drugs was achieved by using dicyclohexyl carbodiimide as activating agent. Optimum parameters (temperature, time, drug concentration, matrix amount, activator concentration) were found.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/actp.1987.010380211
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