ISSN:
1432-136X
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary 1. The relationship between adenylate cyclase, tissue cyclic AMP levels, and dopamine-and serotonin-induced contractile behaviour inAplysia gill was examined. 2. In isolated gill preparations, phasic contractions were evoked by dopamine (EC50, 1 μM) which were mimicked by membrane-permeable analogs of cyclic AMP. Dopamine augmented tissue cyclic AMP levels and stimulated adenylate cyclase in vitro at concentrations analogous to those which produced contractile activity. 3. Serotonin was more efficacious than dopamine in stimulating adenylate cyclase and augmenting cyclic AMP levels. However, very high concentrations of this amine, beyond those which fully saturated adenylate cyclase, were required to produce gill contractions. 4. The cyclic nucleotide did not appear to be involved in the effects of either amine on the gill withdrawal reflex. 5. The effects of dopamine in augmenting spontaneous gill movement may be mediated by cyclic AMP, whereas serotonin-stimulated adenylate cyclase is likely not associated with gill contractility.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00692926
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