Publication Date:
2015-08-08
Description:
Article Omecamtiv Mecarbil (OM) is a small molecule allosteric effector of cardiac myosin in clinical trials for treatment of systolic heart failure. Here the authors determine the crystal structure of an OM-bound human β-cardiac myosin motor domain to provide molecular level insight into the mechanism of drug action. Nature Communications doi: 10.1038/ncomms8974 Authors: Donald A. Winkelmann, Eva Forgacs, Matthew T. Miller, Ann M. Stock
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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