ISSN:
1432-1041
Keywords:
Nicomorphine
;
6-nicotinoylmorphine
;
morphine
;
intramuscular administration
;
metabolism
;
absorption
;
pharmacokinetics
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary After i.m. injection nicomorphine is relatively slowly absorbed from the muscular depot and is found in the serum for approximately 1 h. The rate of absorption differs between patients and governs the overall pharmacokinetic profile of the compound. The relative AUCs were nicomorphine 18%, 6-nicotinoylmorphine 17%, and morphine 65%. Nicomorphine and 6-nicotinoylmorphine have significantly higher AUCs after i.m. injection than after i.v. injection, while the AUC of morphine and the total AUC show no difference between the two modes of administration.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00314971
Permalink