ISSN:
1432-0991
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract. In previous papers (Del Giudice et al. Curr Genet 8:493–497, 1984; Massardo et al. Curr Genet 17:455–457, 1985) we have shown that strains of Saccharomyces cerevisiae that are devoid of mitochondrial DNA (rho o) are resistant to the alkaloid lycorine isolated from Amaryllis plants, whereas strains containing mitochondrial DNA (rho − , mit − , or rho + ) are sensitive to this drug. In addition, we were able to show that the so-called hypersuppressive petites, whose mitochondrial genomes consist of short regions of DNA containing an ori sequence, show intermediate resistance. In this paper, we demonstrate that the degree of suppressiveness of a rho − mutant correlates with the degree of resistance to lycorine.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002849900200
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