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  • 1
    Online Resource
    Online Resource
    Genetics and Epigenetics of Breast Cancer (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Cancer Genetic aspects. ; Cancer Treatment. ; Cancer Biology. ; Cancer Genetics and Genomics. ; Cancer Therapy.
    Description / Table of Contents: Chapter 1. Breast cancer -- Chapter 1.1. Epidemiology -- Chapter 1.2. Etiology -- Chapter 1.3. Types of breast cancer -- Chapter 1.4. Signs and symptoms -- Chapter 1.5. Stages -- Chapter 1.6. Diagnosis -- Chapter 1.7. Treatment -- Chapter 2. Genetic landscape of breast carcinogenesis -- Chapter 2.1. Hormone receptor positive breast cancer -- Chapter 2.1. Her2 positive breast cancer -- Chapter 2.2. Triple negative breast cancer -- Chapter 3. Epigenetic involvement in breast carcinogenesis -- Chapter 3.1. Histone modification -- Chapter 3.2. DNA methylation -- Chapter 3.3. miRNA -- Chapter 4. Breast cancer control -- Chapter 4.1. Conventional drugs targeting Genetic and Epigenetics in Breast cancer -- Chapter 4.2. Pitfalls of conventional therapy -- Chapter 4.3. Natural remediation -- Chapter 5. Conclusion.
    Abstract: This book discusses the contribution of genetics and epigenetics alterations in the initiation, development, and recurrence of breast cancer. It also reviews the potential of translating the epigenetic alterations into diagnosis, prognosis, and breast cancer therapy. The initial chapters explore the epigenetics, etiology, and conventional treatment strategies for breast cancer. The subsequent chapters discuss the genetic landscape and cover three main epigenetic modulation mechanisms; histone modification, DNA methylation, and miRNA silencing. Further, the book explores the potential of epigenetic drugs in treating breast cancer. Lastly, it covers the phytochemicals targeting epigenetic modulators in breast cancer treatment. This book is an essential source for researchers and practitioners interested in exploring the potential of epigenetics modulators in breast cancer treatment.
    Type of Medium: Online Resource
    Pages: X, 87 p. 13 illus., 7 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811999253
    URL: https://doi.org/10.1007/978-981-19-9925-3
    DOI: 10.1007/978-981-19-9925-3
    DDC: 571.978
    Language: English
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  • 2
    Electronic Resource
    Electronic Resource
    Quark masses in a BCS-like approach using $$Q\bar Q$$ potentials (1983)
    Springer
    The European physical journal 19 (1983), S. 179-187 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Using a BCS like equation we have computed constituent quark masses as a function of a parameterC. This parameter is a measure of the effective strength of the interaction for off-the-mass-shell, localised $$q\bar q$$ pairs and is given byC=R/E, whereE is the energy required to separate the pair to a distanceR. Several phenomenological flavour independent $$q\bar q$$ potentials and correlation functions yield results similar in nature. Predictions for distribution functions of intrinsic sea quarks have been made.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01571781
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  • 3
    Electronic Resource
    Electronic Resource
    ΔS=2 processes in ETC models with a left-right symmetric electroweak sector (1985)
    Springer
    The European physical journal 27 (1985), S. 563-567 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract TheK L-K S mass difference in a dynamically broken gauge theory based on aSU(2) L⊗SU(2)R⊗U(1)B-L electroweak sector with manifest left-right symmetry and low right handed mass scale is analysed. We find that consistency with the observedK L-K S mass difference requires a smaller suppression factor than the corresponding quantity in a similar theory based on the standard electroweak sector. The required suppression may be accommodated in this model by reasonable choices of the adjustable parameters of the theory.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01436511
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  • 4
    Electronic Resource
    Electronic Resource
    Z decay constraints on supersymmetric particles revisited (1992)
    Springer
    The European physical journal 54 (1992), S. 513-517 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The allowed regions in the chargino-gluino mass plane are mapped out using the latestZ decay data from experiments. The determination of these masses in future experiments will uniquely fix the neutralino mass spectrum for a fixedv 1/v 2. Since the usual two-fold ambiguity is removed by LEP data for gluino masses upto 200 GeV. Constraints have also been placed on neutralino masses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01559472
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  • 5
    Electronic Resource
    Electronic Resource
    Signatures of virtual LSPs at TEVATRON (1995)
    Springer
    The European physical journal 68 (1995), S. 325-329 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Relatively light sneutrinos which are experimentally allowed and are not theoretically disfavoured may significantly affect the currently popular search strategies for supersymmetric particles by decaying dominantly into an invisible channel. In certain cases the second lightest neutralino may also decay invisibly leading to two extra carriers of missing energy (in addition to the lightest supersymmetric particle (LSP))—the virtual LSPs (VLSPs). The lighter charginos which would be produced in pairs with reasonably large cross-sections at TEVATRON energies, decay dominantly into the hadronically quiet lepton+sneutrino (E T ) modes with large branching ratios leading to interesting unlike sign dilepton events which are not swamped by the standard model background. The kinematical cuts required to eliminate the backgrounds from WW, Drell-Yan and τ pair production are discussed in detail. With 100pb −1 luminosity 10–35 background free events can be found in a large region of the SUSY parameter space.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01566679
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  • 6
    Electronic Resource
    Electronic Resource
    Virtual LSPs at e+ e− colliders (1998)
    Springer
    The European physical journal 1 (1998), S. 375-393 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Currently popular search strategies for supersymmetric particles may be significantly affected due to relatively light sneutrinos which decay dominantly into invisible channels. In certain cases the second lightest neutralino may also decay invisibly leading to two extra carriers of missing energy (in addition to the lightest supersymmetric particle (LSP) ) — the virtual LSPs (VLSPs). A tree lavel calculation shows that if the sneutrino mass happens to be in the small but experimentally allowed range (m ≈ν ≈ 45–55 GeV), these particles together with neutralino pairs may contribute significantly to the missing energy in the process e+e− → γ+ E at LEP-2 energies as an enhancement over the Standard Model or the conventional MSSM predictions. It is further shown that a much larger region of the parameter space can be scanned at a high luminosity e+e− collider at 500 GeV like the proposed NLC machine. Moreover, at both LEP-2 and NLC this process may play a complementary role to direct chargino searches, which may fail due to a near mass degeneracy of the chargino and the sneutrino. Formulae for the cross sections taking into account full mixings of the charginos and the neutralinos are derived. The signal remains observable even in the context of more restricted models based onN=1 SUGRA with common scalar and gaugino masses. A preliminary study of the QED radiative corrections due to soft multiple photon emission as well as hard collinear bremsstrahlung indicates that these corrections play a crucial role in estimating the background.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01245828
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  • 7
    Electronic Resource
    Electronic Resource
    theK L-K S mass difference in left-right symmetric models and the right-handed Kobayashi-Maskawa matrix (1983)
    Springer
    The European physical journal 20 (1983), S. 305-312 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract K L-K S mass difference is computed in a left-right symmetric model with three generations of quarks. Under the assumption of “manifest” left-right symmetry the mass of the right-handed charged gauge boson consistent withK L-K S constraint appears to be rather high. A low mass right-handed gauge boson can be accommodated in models with broken “manifest” left-right symmetry. The latter scenario has many non-trivial predictions for the decay of heavy (c, t, b) quarks.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01407822
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  • 8
    Electronic Resource
    Electronic Resource
    $$D^0 - \bar D^0 $$ mixing: A possible test of physics beyond the Standard Model (1985)
    Springer
    The European physical journal 27 (1985), S. 515-522 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract It is shown that the $$D^0 - \bar D^0 $$ mixing is strongly suppressed in the Standard Model and is smaller by several orders of magnitude than the current experimental upper-bound. The detection of a stronger $$D^0 - \bar D^0 $$ mixing in the future experiments might indicate the existence of a new physics beyond the Standard Model. As an example, it is shown that in a class of simple super-symmetric theories $$D^0 - \bar D^0 $$ mixing could be substantially larger than the Standard Model prediction. If on the other hand the Standard Model prediction is confirmed by future experiments that will require that the super-symmetric extension of the standard model should have a much larger SUSY breaking scale than that indicated by the phenomenology of the neutral kaon system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01436505
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  • 9
    Electronic Resource
    Electronic Resource
    Virtual LSPs at e $^+$ e $^-$ colliders (1998)
    Springer
    The European physical journal 1 (1998), S. 375-393 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract. Currently popular search strategies for supersymmetric particles may be significantly affected due to relatively light sneutrinos which decay dominantly into invisible channels. In certain cases the second lightest neutralino may also decay invisibly leading to two extra carriers of missing energy (in addition to the lightest supersymmetric particle (LSP) ) – the virtual LSPs (VLSPs). A tree lavel calculation shows that if the sneutrino mass happens to be in the small but experimentally allowed range ( $m_{\bar\nu} \approx$ 45-55 GeV), these particles together with neutralino pairs may contribute significantly to the missing energy in the process $e^+ e^- \longrightarrow \gamma + \not \!\!{E}$ at LEP-2 energies as an enhancement over the Standard Model or the conventional MSSM predictions. It is further shown that a much larger region of the parameter space can be scanned at a high luminosity $e^+ e^-$ collider at 500 GeV like the proposed NLC machine. Moreover, at both LEP-2 and NLC this process may play a complementary role to direct chargino searches, which may fail due to a near mass degeneracy of the chargino and the sneutrino. Formulae for the cross sections taking into account full mixings of the charginos and the neutralinos are derived. The signal remains observable even in the context of more restricted models based on $N$ =1 SUGRA with common scalar and gaugino masses. A preliminary study of the QED radiative corrections due to soft multiple photon emission as well as hard collinear bremsstrahlung indicates that these corrections play a crucial role in estimating the background.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01245828
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  • 10
    Electronic Resource
    Electronic Resource
    Constraints on the squark mass matrix from CP-violation and SUSY predictions for the $$B^0 - \bar B^0 $$ systems (1986)
    Springer
    The European physical journal 32 (1986), S. 591-597 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The parametersc andA of the squark mass matrix, which control flavour violation and left-right maxing respectively, are constrained by fitting ∈ and ∈′. The predictions for mixing and CP-violation in the $$B^0 - \bar B^0 $$ system are calculated and then compared with both the predictions of the standard model and the available experimental data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01550784
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