ISSN:
1573-1111
Keywords:
metallo-cyclodextrin
;
enantioselectivity
;
amino acid
;
binary complex
;
ternary complex
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Enantioselectivity towards several amino acids by metallo-6A-deoxy-6A-hydroxyethyl-amino-β-cyclodextrins (metallo-βCDea's) was investigated by potentiometric titration of the various amino acid/metallo-βCDea systems with NaOH solution. It was shown that the cyclodextrin derivative is capable of distinguishing between enantiomers of amino acid species in the presence of certain metal ions (Co2+, Ni2+, Cu2+and Zn2+). Ni2+-βCDea complexes show the most enantioselectivity, whereas for Cu2+- and Co2+-βCDea complexes less selectivity is observed. As expected, Zn2+-βCDea complexes exhibit no enantioselectivity. Stability and selectivity, however, do not go hand in hand, since the most stable complexes are formed with Cu2+. Several factors play a role in determining stability and selectivity in binary and ternary complexes and further study is required to gain a more comprehensive understanding of these.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1008012023662
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