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  • 1
    Electronic Resource
    Electronic Resource
    Adhesion of microvascular endothelial cells to metallic implant surfaces (2000)
    Springer
    Journal of materials science 11 (2000), S. 279-285 
    Details
    ISSN: 1573-4838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract The objective of this study was to explore the molecular mechanisms of adhesion of endothelial cells (ECs) to implant grades of titanium alloy (Ti) and stainless steel (SS), compared to tissue culture polystyrene (PS). The idea is that promotion of EC adhesion to implant surfaces during the initial stages of healing may be critical in the formation of a capillary bed intimately associated with the implant surface. Ultimately this could be expected in turn to promote bone formation close to the surface and a more stable implant/bone interface. Surfaces were coated with either peak 1 fibrinogen γAγA, fibrinogen Fr I-9, fibrinogen fragment D1, fibronectin, vitronectin, or fetal calf serum and then post-coated with bovine serum albumin (BSA) to block non-specific cell adhesion. Surfaces with BSA alone and no other protein coating were also evaluated. Fibronectin coating maximized cell adhesion on all three surfaces, and adhesion was highest on PS. BSA blocked cell adhesion to PS (and most adhesion to SS) much better than to Ti. These results provide evidence that BSA adsorption on the metal surface is unable to effectively block the adhesion of the cells to the Ti. These data may provide a basis for understanding in vivo observations that soft tissue becomes attached to a Ti surface more rapidly and with more bone formation than to SS. Evidence is also presented that αvβ3 plays an important role in adhesion of ECs to the Ti surface. These experiments also provide preliminary data which may reflect some of the features of initial EC adhesion to metal implants. ©2000 Kluwer Academic Publishers
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008953112683
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  • 2
    Electronic Resource
    Electronic Resource
    A new method for continuous intraoperative measurement of Harrington rod loading patterns (1984)
    Springer
    Annals of biomedical engineering 12 (1984), S. 233-246 
    Details
    ISSN: 1573-9686
    Keywords: Harrington rod ; Spine ; Scoliosis ; Loads and strain gauge
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract A new method has been developed for continuous intra-operative monitoring of bone and implant loading patterns in the operative correction of scoliosis using the Harrington distraction rod. The method incorporates a strain gauge instrumented, distal Harrington hook and similarly equipped Harrington operating instruments (outrigger and distractor). These latter instruments are used to calibrate the hook's response to bone loads under existing operative conditions. Alternative methods of monitoring loading patterns were explored and rejected because they were noncontinuous, more difficult to use, altered the mechanics of the system, or required more expensive components. The method established is being used to avoid bone rupture or rod damage while gaining maximum spinal correction and to determine the effect of auxiliary implant components on loading patterns.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02364308
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  • 3
    Electronic Resource
    Electronic Resource
    Applied biomaterials standards report (1991)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Biomaterials 2 (1991), S. 59-60 
    Details
    ISSN: 1045-4861
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: The purpose of my column is to provide readers with current information on biomaterials-related standards produced by both private groups and government agencies, and standards-related activities. Standards are descriptive documents given official status by their producers, and in the case of biomaterials, they are generally intended to provide formalized descriptions of (a) materials used in the construction of medical devices, (b) materials used directly in surgical repairs, (c) test methods to evaluate materials for such applications, and (d) methods for handling or processing such materials.Please consider this column not only a place to obtain biomaterials standards information, but also a place to submit news of biomaterials standards developments in order to get the information before the public. This invitation extends to members of all professional organizations and government agencies in the United States and abroad who are active in standards development and would like specific activities or standards publicized. I will present the information in this column to the extent that allotted space allows.And last, a caveat - since this is a column, it contains both factual information and opinions. I will make every effort to make it clear which is which. Also, as a frame of reference, please note that this column was written and submitted in November 1990.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jab.770020111
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  • 4
    Electronic Resource
    Electronic Resource
    The effect of screw fixation on initial rigidity of tibial knee components (1991)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Biomaterials 2 (1991), S. 109-113 
    Details
    ISSN: 1045-4861
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Initial rigid fixation is essential for bone ingrowth into a porous-coated prosthesis. In this study, the amount of micromotion between a cut tibial surface and a custom tibial base-plate mounted with various types of screw fixation was measured. Motion transducers were placed at the corners of the baseplate to detect liftoff and subsidence. Central and eccentric loads were then applied. The variables tested included screw number and position, as well as screw length and type of bone purchase.A four-screw peripheral configuration had less micromotion than a three-screw triangulated configuration, and both had less micromotion than a two-screw central condyle configuration. Long screws with cancellous purchase and screws with cortical purchase had less micromotion than short screws with cancellous purchase.These results indicate that important variables which contribute to the initial rigidity of a cementless tibial implant using screw fixation include screw number, configuration, length, and type of bone purchase.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jab.770020206
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  • 5
    Electronic Resource
    Electronic Resource
    Applied Biomaterials Standards Report (1991)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Biomaterials 2 (1991), S. 141-142 
    Details
    ISSN: 1045-4861
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: The purpose of my column is to provide readers with current information on biomaterials-related standards produced by both private groups and government agencies, and also on standards-related activities. Standards are descriptive documents given official status by their producers, and in the case of biomaterials, they are generally intended to provide formalized descriptions of (a) materials used in the construction of medical devices, (b) materials used directly in surgical repairs, (c) test methods to evaluate materials for such applications, and (d) methods for handling or processing such materials.Please consider this column not only a place to obtain biomaterials standards information, but also a place to submit news of biomaterials standards developments in order to get the information before the public. This invitation extends to members of all professional organizations and government agencies in the United States and abroad who are active in standards development and would like specific activities or standards publicized. I will present the information in this column to the extent that allotted space allows.And last, a caveat-since this is a column, it contains both factual information and opinions. I will make every effort to make it clear which is which. Also, as a frame of reference, please note that this column was written and submitted in March 1991.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jab.770020210
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  • 6
    Electronic Resource
    Electronic Resource
    Effectiveness of silane treatment on absorbable microfibers (1992)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Biomaterials 3 (1992), S. 191-195 
    Details
    ISSN: 1045-4861
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Preliminary experiments suggest pretreatment of absorbable crystalline, calcium-sodium-metaphosphate (CSM) microfibers with trimethoxy-based silane coupling agents yields a polysiloxane film barrier which protects the fiber surface from early dissolution due to water. Compared to thermoplastic poly(L-lactic acid) (PLLA) composites reinforced with untreated fibers, PLLA composites reinforced with a variety of silane pretreated microfibers showed increased mechanical properties, suggesting improved adhesion was achieved at the fiber/matrix interface. Unfortunately, the silane pretreated CSM/PLLA composite showed no increase in wet strength retention after short-term in vitro exposure. This may be due to plasticization from water entering the composite at areas of incomplete fiber wetting by the highly viscous molten PLLA. However, when a nonabsorbable, low viscosity unsaturated polyester thermoset resin was reinforced with methacryloxy-silane pretreated CSM microfibers, there was no decrease in flexural strength and less than a 10% decrease in flexural modulus after 7 days exposure to 7.4 pH Tris-buffered saline at 37°C.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jab.770030305
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  • 7
    Electronic Resource
    Electronic Resource
    Biocompatibility and mechanical properties of a totally absorbable composite material for orthopaedic fixation devices (1992)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Biomaterials 3 (1992), S. 197-206 
    Details
    ISSN: 1045-4861
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Bioabsorbable polymer/inorganic phosphate fiber composites are prone to rapid degradation due to water sensitivity of the interface between the degradable polymer and the degradable fiber. This article describes successful fabrication and laboratory evaluation of a candidate bioabsorbable composite implant material with mechanical properties similar to bone. The composite studied was poly(ortho ester) reinforced with randomly-oriented, crystalline microfibers of calcium-sodium-metaphosphate. The component materials showed no acute cytotoxicity as determined by tissue culture agar overlay. Treating the microfibers with a diamine-silane coupling agent improved mechanical properties and slowed degradation in saline, but strength still decreased 50% in 1 week. When the composite material was then coated with a layer of matrix polymer alone it retained 70% of its strength and 70% of its stiffness after 4 weeks exposure to 7.4 pH Tris-buffered saline at body temperature. The marked improvement with the coating can be attributed to the hydrophobicity of poly(ortho esters).
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jab.770030306
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  • 8
    Electronic Resource
    Electronic Resource
    Applied Biomaterials Standards Report (1991)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Biomaterials 2 (1991), S. 209-210 
    Details
    ISSN: 1045-4861
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: The purpose of my column is to provide readers with current information on biomaterials related standards produced by both private groups and government agencies, and also on standards-related activities. Standards are descriptive documents given official status by their producers, and in the case of biomaterials, they are generally intended to provide formalized descriptions, of (a) materials used in the construction of medical devices, (b) materials used directly in surgical repairs, (c) test methods to evaluate materials for such applications, and (d) methods for handling or processing such materials.Please consider this column not only a place to obtain biomaterials standards information, but also a place to submit news of biomaterials standards developments in order to get the information before the public. This invitation extends to members of all professional organizations and government agencies in the United States and abroad who are active in standards development and would like specific activities or standards publicized. I will present the information in this column to the extent that allotted space allows.At last, a caveat-since this is a column, it contains both factual information and opinions. I will make every effort to make it clear which is which. Also, as a frame of reference, please note that this column was written and submitted in June 1991.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jab.770020308
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  • 9
    Electronic Resource
    Electronic Resource
    Applied biomaterials standards report (1990)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Biomaterials 1 (1990), S. 331-332 
    Details
    ISSN: 1045-4861
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: The purpose of my column is to provide readers with current information on biomaterialsrelated standards produced by both private groups and government agencies, and standards-related activities. Standards are descriptive documents given official status by their producers, and in the case of biomaterials, they are generally intended to provide formalized descriptions of (a) materials used in the construction of medical devices, (b) materials used directly in surgical repairs, (c) test methods to evaluate materials for such applications, and (d) methods for handling or processing such materials.Please consider this column not only a place to obtain biomaterials standards information, but also a place to submit news of biomaterials standards developments in order to get the information before the public. This inviation extends to members of all professional organizations and government agencies in the United States and abroad who are active in standards development and would like specific activities or standards publicized. I will present the information in this column to the extent that allotted space allows.And last, a caveat-since this is a column, it contains both factual information and opinions. I will make every effort to make it clear which is which. Also, as a frame of reference, please note that this column was written and submitted in September 1990.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jab.770010410
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  • 10
    Electronic Resource
    Electronic Resource
    Mechanical test methodology for environmental exposure testing of biodegradable polymers (1991)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Biomaterials 2 (1991), S. 13-22 
    Details
    ISSN: 1045-4861
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: A test methodology was developed for exposing degradable polymer test specimens to a simulated chemical and mechanical body environment and then testing them periodically to detect changes in stress-strain behavior. Poly(ortho ester) specimens were exposed to cyclic loading in aerated tris-buffered saline (pH = 7.4) at 37°C. Specimens were removed at various time periods and the mechanical properties determined. To determine the effects of cyclic loading alone, additional specimens were cycled in air for the same cyclic periods and tested in the same manner. To determine the effects of a constant load on degradation rate, other specimens were subjected to a static load while exposed to trisbuffered saline. Additional specimens were subjected to immersion in tris-buffered saline without loading.Exposure to tris-buffered saline alone had a small effect on the rate of change of the mechanical properties of the poly(ortho ester) specimens while cyclic loading in air alone had no effect. However a combination of both exposure to tris-buffered saline and a static load decreased the flexural yield strength by 29% and the modulus of elasticity by 20% after 40 days, and a combination of both exposure to tris-buffered saline and cyclic loading decreased both the flexural strength and modulus by 75% after 40 days.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jab.770020103
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