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  • 1
    Electronic Resource
    Electronic Resource
    Effect of Drugs on Contractions of Vertebrate Smooth Muscle (1964)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Pharmacology 4 (1964), S. 189-222 
    Details
    ISSN: 0362-1642
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.pa.04.040164.001201
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  • 2
    Electronic Resource
    Electronic Resource
    Digestion: Motor Function (1969)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 31 (1969), S. 203-226 
    Details
    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.ph.31.030169.001223
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  • 3
    Electronic Resource
    Electronic Resource
    The Generation and Conduction of Activity in Smooth Muscle (1978)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Pharmacology 18 (1978), S. 145-166 
    Details
    ISSN: 0362-1642
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.pa.18.040178.001045
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  • 4
    Electronic Resource
    Electronic Resource
    NEUROTENSIN, EVIDENCE FOR MULTIPLE RECEPTORS FOR GASTROINTESTINAL MOTILITY ACTION IN DOGS (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 400 (1982), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1982.tb31592.x
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  • 5
    Electronic Resource
    Electronic Resource
    Is the nexus necessary for cell-to-cell coupling of smooth muscle? (1976)
    Springer
    The journal of membrane biology 28 (1976), S. 207-239 
    Details
    ISSN: 1432-1424
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary Electronmicroscopic study of electrically coupled smooth muscles was undertaken to determine the distribution of nexuses in various types of smooth muscle. The study revealed that while nexal structures were commonplace in some types of smooth muscle, they were very rare or absent in others, even though in some cases these cells were only a few nanometers distant from one another. The persistence in thin section of these structures in the main circular muscle of dog intestine after poor fixation, fixation under strain, cell shrinkage, and metabolic damage of various sorts seems to rule out the thesis that they are labile. The absence of nexuses in longitudinal muscle of dog intestine examined both by thin section and by freeze fracture suggests that in this tissue they are absent or very rarein vivo and cannot account for electrical coupling. Nexuses were discernible in thin sections of main circular muscle after a variety of experimental conditions of fixation. Metabolic inhibition orin vitro permanganate fixation partially destroyed nexal contacts. These procedures induced tissue, membrane apposition and an accompanying increase in the number of structures which resemble nexuses at low magnification (nexus-like structures). “Nexus-like” structures occurred in all smooth muscle fixed byin vitro permanganate associated with apposition of membranes and poor preservation of basement membrane. A technique ofin vitro permanganate fixation was developed which prevented tissue swelling; consequently “nexus-like” structures were absent in tissues so treated. The suggestion is made that some structures described in the literature as nexuses, following permanganate fixation, may represent “nexus-like” structures. The balance of evidence suggests that nexuses need not be present for electrical coupling of some smooth muscle cells, in which other types of cell-to-cell contacts must be invoked.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01869698
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  • 6
    Electronic Resource
    Electronic Resource
    Imidazole inhibits a temperature-dependent component of mammalian skeletal muscle action potential (1980)
    [s.l.] : Nature Publishing Group
    Nature 283 (1980), S. 485-486 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Extensor digitorum longus muscles from male Wistar rats were mounted in a muscle bath and perfused with oxygenated Ringer's solution. The temperature of the bath was regulated by water circulating around its jacket. Intracellular recordings were made with microelectrodes filled with 3M KC1. The ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/283485a0
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  • 7
    Electronic Resource
    Electronic Resource
    Electrical Activity in Human Uterine Muscle Strips (1965)
    [s.l.] : Nature Publishing Group
    Nature 208 (1965), S. 290-291 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We have succeeded in recording action potentials from human uterine muscle strips. The amplitude and speed of propagation of the potentials have been correlated with the mechanical action in non-pregnant and pregnant human myometrial strips. In the non-pregnant patients the muscle strips were ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/208290a0
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  • 8
    Electronic Resource
    Electronic Resource
    The use of subcellular membrane fractions in analysis of control of smooth muscle function (1985)
    Springer
    Cellular and molecular life sciences 41 (1985), S. 905-913 
    Details
    ISSN: 1420-9071
    Keywords: Smooth muscle ; plasma membrane ; Ca transport ; Ca pump ; Ca binding ; Na−Ca exchange
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Conclusions 1) Use of purified subcellular membranes from smooth muscle offers an approach to study mechanisms of Ca-handling which may eliminate some problems which have delayed progress and confused interpretation of experiments with intact tissues. 2) With techniques available to date it has been possible to obtain satisfactorily purified plasma membrane vesicles and mitochondria, but endoplasmic reticulum vesicles have not been obtained in satisfactory purity. 3) Failure to isolate pure endoplasmic reticulum fractions may be caused by its similar densities to plasma membrane and to the larger quantity of plasma membrane as well as by differential damage to ER vesicles by the isolation techniques used. If oxalate-activation of ATP-dependent Ca2+-transport proves to be a property unique to ER, the resultant increase in density of ER vesicles will aid their isolation. If so, and if the causes of differential loss of this transport function during isolation can be identified and avoided, then study of the properties of purified endoplasmic reticulum should be possible. 4) Purified plasma membrane vesicles have been shown to possess(soL) a) an ATP-dependent pump capable of extruding Ca2+ from cell and lowering the internal Ca2+ to about 10−7 M; b) a Na−Ca2+ exchange system which appears to have a limited velocity and capacity compared to heart and to nerve, but so far it has not been studied unter optimal conditions (e.g. with a maintained Na+ gradient); c) a pH-dependent, ATP-dependent, high affinity Ca binding which may participate in excitation-contraction coupling; d) a pH-independent, low affinity Ca-binding which has not been studied in detail.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01970009
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  • 9
    Electronic Resource
    Electronic Resource
    Dense-cored membranous structures in smooth muscle cells of the vas deferens of the rat (1984)
    Springer
    Cell & tissue research 235 (1984), S. 43-49 
    Details
    ISSN: 1432-0878
    Keywords: Vas deferens ; Dense-cored vesicles and tubules ; Plasma membrane infoldings ; Smooth muscle cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Smooth muscle cells from rat vas deferens were studied by electron microscopy. Vesicular and tubular membranous structures containing an electron-opaque material were found in the smooth muscle cells. Similar structures were also found in a subfraction (F3) of microsomes of vas deferens smooth muscle which was shown to be rich in both plasma membrane and putative endoplasmic reticulum markers. Treatment of the tissues with calcium-free Krebs solution containing EGTA prior to fixation eliminated almost completely the presence of these dense-cored membranous structures (DMS), whereas incubation of the subcellular membrane fraction with EGTA solution had no effect on the appearance of the DMS. Plasma membrane infoldings were found in the smooth muscle cells extending well into their interior. Horseradish peroxidase penetrates vesicles in a location similar to that of DMS in smooth muscle cells, suggesting that some of the DMS may be connected to the extracellular space. We conclude that the dense-core material within the DMS is calcium dependent. We also suggest that some of the DMS represent infoldings of the plasma membrane extending into the cell's interior.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00213721
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  • 10
    Electronic Resource
    Electronic Resource
    The projections of chemically identified nerve fibres in canine ileum (1987)
    Springer
    Cell & tissue research 247 (1987), S. 377-384 
    Details
    ISSN: 1432-0878
    Keywords: Enkephalin ; Gastrin releasing peptide ; Neuropeptide Y ; Somatostatin ; Substance P ; Vasoactive intestinal peptide ; Enteric nervous system ; Intestine, small ; Dog
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The projections of nerve fibres with immunoreactivity for the peptides enkephalin (ENK), gastrin-releasing peptide (GRP), neuropeptide Y (NPY), somatostatin (SOM), substance P (SP) and vasoactive intestinal peptide (VIP) were studied in canine small intestine by analysing the consequences of lesions of intrinsic and extrinsic nerves. Of peptides present in fibres supplying myenteric ganglia, GRP, SOM and VIP were in anally directed nerve pathways, whereas ENK and NPY were in orally directed pathways. Pathways ran for up to about 30 mm. SP fibres ran for short distances in both directions in the myenteric plexus. The circular muscle was supplied with ENK, NPY, SP and VIP fibres arising from the myenteric ganglia, whereas most mucosal SP and VIP fibres were deduced to arise from submucous ganglia. There were projections of fibres reactive for ENK, GRP, SOM, SP and VIP from myenteric ganglia to submucous ganglia. Antibodies to tyrosine hydroxylase were used to locate noradrenaline nerve fibres supplying the intestine; these fibres all disappeared when extrinsic nerves running through the mesentery to the small intestine were cut. It is deduced that there is an ordered pattern of projections of peptide-containing fibres in the canine intestine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00218319
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