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  • 1
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    Alternative RUNX1 Promoter Regulation by Wnt/β-Catenin Signaling in Leukemia Cells and Human Hematopoietic Progenitors (2015)
    Wiley
    Details
    Publication Date: 2015-11-19
    Description: Two distantly located promoter regions regulate the dynamic expression of RUNX genes during development: distal P1 and proximal P2 promoters. We have recently described that β-catenin increases total Runx1 mRNA levels in human CD34 + hematopoietic progenitors and enhances spatial proximity with its translocation partner ETO. Here we report that induction of Wnt/β-catenin signaling in HL60 and Jurkat leukemia-derived cell lines and CD34 + progenitors selectively activate the production of the longer distal P1-Runx1 mRNA isoform. Gain- and loss-of-function experiments revealed that the differential increase in P1-Runx1 expression is accomplished through a minimal β-catenin responsive region that includes a highly conserved TCF/LEF-binding element, located -20/-16 bp upstream of the canonical distal P1-Runx1 transcription start site. We conclude that the distal P1-Runx1 promoter is a direct transcriptional target of Wnt/β-catenin signaling that may be important in normal hematopoiesis or its transition into malignant stem cells during the onset or progression of leukemia. This article is protected by copyright. All rights reserved
    Electronic ISSN: 1097-4652
    Topics: Biology , Medicine
    Published by Wiley
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  • 2
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    Enhanced Eshelby Twist on Thin Wurtzite InP Nanowires and Measurement of Local Crystal Rotation (2011)
    American Physical Society (APS)
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    Publication Date: 2011-11-05
    Description: Author(s): L. H. G. Tizei, A. J. Craven, L. F. Zagonel, M. Tencé, O. Stéphan, T. Chiaramonte, M. A. Cotta, and D. Ugarte [Phys. Rev. Lett. 107, 195503] Published Fri Nov 04, 2011
    Keywords: Condensed Matter: Structure, etc.
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
    Published by American Physical Society (APS)
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  • 3
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    Intrinsic Stability of the Smallest Possible Silver Nanotube (2011)
    American Physical Society (APS)
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    Publication Date: 2011-02-10
    Description: Author(s): P. A. S. Autreto, M. J. Lagos, F. Sato, J. Bettini, A. R. Rocha, V. Rodrigues, D. Ugarte, and D. S. Galvao Recently, Lagos et al. [Nature Nanotech. 4, 149 (2009)] reported the discovery of the smallest possible Ag nanotube with a square cross section. Ab initio density functional theory calculations strongly support that the stability of these hollow structures is structurally intrinsic and not the res... [Phys. Rev. Lett. 106, 065501] Published Wed Feb 09, 2011
    Keywords: Condensed Matter: Structure, etc.
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
    Published by American Physical Society (APS)
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  • 4
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    Mechanical Deformation of Nanoscale Metal Rods: When Size and Shape Matter (2011)
    American Physical Society (APS)
    Details
    Publication Date: 2011-02-03
    Description: Author(s): M. J. Lagos, F. Sato, D. S. Galvão, and D. Ugarte Face centered cubic metals deform mainly by propagating partial dislocations generating planar fault ribbons. How do metals deform if the size is smaller than the fault ribbons? We studied the elongation of Au and Pt nanorods by in situ electron microscopy and ab initio calculations. Planar fault ... [Phys. Rev. Lett. 106, 055501] Published Wed Feb 02, 2011
    Keywords: Condensed Matter: Structure, etc.
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
    Published by American Physical Society (APS)
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  • 5
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    Electrostatic deflections and electromechanical resonances of carbon nanotubes (1999)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1999-03-05
    Description: Static and dynamic mechanical deflections were electrically induced in cantilevered, multiwalled carbon nanotubes in a transmission electron microscope. The nanotubes were resonantly excited at the fundamental frequency and higher harmonics as revealed by their deflected contours, which correspond closely to those determined for cantilevered elastic beams. The elastic bending modulus as a function of diameter was found to decrease sharply (from about 1 to 0.1 terapascals) with increasing diameter (from 8 to 40 nanometers), which indicates a crossover from a uniform elastic mode to an elastic mode that involves wavelike distortions in the nanotube. The quality factors of the resonances are on the order of 500. The methods developed here have been applied to a nanobalance for nanoscopic particles and also to a Kelvin probe based on nanotubes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Poncharal -- Wang -- Ugarte -- de Heer WA -- New York, N.Y. -- Science. 1999 Mar 5;283(5407):1513-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Physics, Georgia Institute of Technology, Atlanta, GA 30332-0430, USA. School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, GA 30332-0245, USA. Laboratorio National de Luz Sincrotron, Cx P.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10066169" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Liquid carbon, carbon-glass beads, and the crystallization of carbon nanotubes (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-02-12
    Description: The formation of carbon nanotubes in a pure carbon arc in a helium atmosphere is found to involve liquid carbon. Electron microscopy shows a viscous liquid-like amorphous carbon layer covering the surfaces of nanotube-containing millimeter-sized columnar structures from which the cathode deposit is composed. Regularly spaced, submicrometer-sized spherical beads of amorphous carbon are often found on the nanotubes at the surfaces of these columns. Apparently, at the anode, liquid-carbon drops form, which acquire a carbon-glass surface due to rapid evaporative cooling. Nanotubes crystallize inside the supercooled, glass-coated liquid-carbon drops. The carbon-glass layer ultimately coats and beads on the nanotubes near the surface.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉de Heer, Walt A -- Poncharal, Philippe -- Berger, Claire -- Gezo, Joseph -- Song, Zhimin -- Bettini, Jefferson -- Ugarte, Daniel -- New York, N.Y. -- Science. 2005 Feb 11;307(5711):907-10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Physics, Georgia Institute of Technology, Atlanta, GA 30332, USA. walt.deheer@physics.gatech.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15705847" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Aligned carbon nanotube films: production and optical and electronic properties (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-05-12
    Description: Carbon nanotube material can now be produced in macroscopic quantities. However, the raw material has a disordered structure, which restricts investigations of both the properties and applications of the nanotubes. A method has been developed to produce thin films of aligned carbon nanotubes. The tubes can be aligned either parallel or perpendicular to the surface, as verified by scanning electron microscopy. The parallel aligned surfaces are birefringent, reflecting differences in the dielectric function along and normal to the tubes. The electrical resistivities are anisotropic as well, being smaller along the tubes than perpendicular to them, because of corresponding differences in the electronic transport properties.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Deheer, W A -- Bacsa, W S -- Chatelain, A -- Gerfin, T -- Humphrey-Baker, R -- Forro, L -- Ugarte, D -- New York, N.Y. -- Science. 1995 May 12;268(5212):845-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17792177" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Nanocapillarity and Chemistry in Carbon Nanotubes (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-12-13
    Description: Open carbon nanotubes were filled with molten silver nitrate by capillary forces. Only those tubes with inner diameters of 4 nanometers or more were filled, suggesting a capillarity size dependence as a result of the lowering of the nanotube-salt interface energy with increasing curvature of the nanotube walls. Nanotube cavities should also be less chemically reactive than graphite and may serve as nanosize test tubes. This property has been illustrated by monitoring the decomposition of silver nitrate within nanotubes in situ in an electron microscope, which produced chains of silver nanobeads separated by high-pressure gas pockets.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ugarte -- Chatelain -- de Heer WA -- New York, N.Y. -- Science. 1996 Dec 13;274(5294):1897-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉D. Ugarte, Laboratorio Nacional de Luz Sincrotron (CNPq/MCT), Caixa Postal 6192, 13083-970 Campinas SP, Brazil. A. Chatelain, Institut de Physique Experimentale, Departement Physique, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland. W. A. de Heer, School of Physics, Georgia Institute of Technology, Atlanta, GA 30332, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8943200" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Interpolation of daily rainfall using spatiotemporal models and clustering (2014)
    Wiley
    Details
    Publication Date: 2014-06-12
    Description: ABSTRACT Accumulated daily rainfall in non-observed locations on a particular day is frequently required as input to decision-making tools in precision agriculture or for hydrological or meteorological studies. Various solutions and estimation procedures have been proposed in the literature depending on the auxiliary information and the availability of data, but most such solutions are oriented to interpolating spatial data without incorporating temporal dependence. When data are available in space and time, spatiotemporal models usually provide better solutions. Here, we analyse the performance of three spatiotemporal models fitted to the whole sampled set and to clusters within the sampled set. The data consists of daily observations collected from 87 manual rainfall gauges from 1990 to 2010 in Navarre, Spain. The accuracy and precision of the interpolated data are compared with real data from 33 automated rainfall gauges in the same region, but placed in different locations than the manual rainfall gauges. Root mean squared error by months and by year are also provided. To illustrate these models, we also map interpolated daily precipitations and standard errors on a 1 km 2 grid in the whole region.
    Print ISSN: 0899-8418
    Electronic ISSN: 1097-0088
    Topics: Geosciences , Physics
    Published by Wiley
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  • 10
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    Transcription of the pain-related TRPV1 gene requires Runx1 and C/EBPβ factors (2012)
    Wiley
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    Publication Date: 2012-09-28
    Description: Transient Receptor Potential Vanilloid type 1 channel (TRPV1) is an important endogenous transducer of noxious heat and chemical stimuli and is required during development of inflammatory hypersensitivity. The transcription factor Runx1 is known to play a relevant role in sensory neuron differentiation as it controls the expression of several sensory nociceptive receptors, including TRPV1. Here, we show that Runx1 up-regulates TRPV1 transcription activity by interacting directly with the proximal TRPV1 gene promoter sequence. Importantly, C/EBPβ a well-established heterodimer partner of Runx1 also binds to the TRPV1 promoter and cooperates with Runx1 to further stimulate TRPV1 transcription. Our results support a mechanism where Runx1-C/EBPβ-containing transcription regulatory complexes are recruited to the TRPV1 gene promoter to modulate TRPV1 expression in dorsal root ganglia neurons. J. Cell. Physiol. © 2012 Wiley Periodicals, Inc.
    Electronic ISSN: 1097-4652
    Topics: Biology , Medicine
    Published by Wiley
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