Publication Date:
1988-04-01
Description:
Individuals infected with the human immunodeficiency virus type 1 (HIV-1) may be asymptomatic or have AIDS-related complex or the acquired immuno deficiency syndrome (AIDS). Little is known about the factors that influence progression of infection to AIDS. In this study of isolates of HIV-1 obtained at intervals during the infection of four individuals, the development of disease was found to be correlated with the emergence of HIV-1 variants that were more cytopathic in vitro as the disease progressed and that replicated more efficiently in a wide variety of different human cells. The biologic properties of HIV-1 in vitro thus appear to reflect its virulence in the host. Further studies of such sequentially isolated viruses may lead to the identification of viral genes that govern pathogenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cheng-Mayer, C -- Seto, D -- Tateno, M -- Levy, J A -- P01 AI-24286/AI/NIAID NIH HHS/ -- R01 AI-24499/AI/NIAID NIH HHS/ -- R01 AI-25284/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1988 Apr 1;240(4848):80-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, University of California, School of Medicine, San Francisco 94143.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2832945" target="_blank"〉PubMed〈/a〉
Keywords:
AIDS-Related Complex/etiology/microbiology
;
Acquired Immunodeficiency Syndrome/etiology/microbiology
;
Cytopathogenic Effect, Viral
;
DNA/genetics
;
Genetic Variation
;
HIV/genetics/*pathogenicity/physiology
;
HIV Envelope Protein gp120
;
Humans
;
Neutralization Tests
;
Retroviridae Proteins/genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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