Publication Date:
1979-04-20
Description:
Chloroxymorphamine, the 6beta-N,N-bis(2-chloroethyl) derivative of oxymorphone, is a potent nonequilibrium narcotic agonist in the longitudinal muscle preparation of guinea pig ileum. The corresponding naltrexone analog,chlornaltrexamine, is a potent nonequilibrium antagonist of morphine. These receptor sitedirected alkylating agents possess considerable potenial as pharmacologic and biochemical probes of apoid receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Caruso, T P -- Takemori, A E -- Larson, D L -- Portoghese, P S -- New York, N.Y. -- Science. 1979 Apr 20;204(4390):316-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/86208" target="_blank"〉PubMed〈/a〉
Keywords:
*Alkylating Agents
;
Animals
;
Chlorambucil/pharmacology
;
Dose-Response Relationship, Drug
;
Drug Synergism
;
Guinea Pigs
;
Hydromorphone/*analogs & derivatives
;
In Vitro Techniques
;
Morphine/pharmacology
;
Naloxone/pharmacology
;
Naltrexone/analogs & derivatives/pharmacology
;
Nitrogen Mustard Compounds/*pharmacology
;
Norepinephrine/pharmacology
;
Oxymorphone/*analogs & derivatives/pharmacology
;
Phenoxybenzamine/pharmacology
;
Receptors, Opioid/*drug effects
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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