Publication Date:
1997-10-23
Description:
Long-term potentiation (LTP) is considered an important neuronal mechanism of learning and memory. Currently, however, there is no direct experimental link between LTP of an identified synapse and learning. A cellular analog of classical conditioning in Aplysia was used to determine whether this form of invertebrate learning involves N-methyl-D-aspartate (NMDA)-type LTP. The NMDA receptor-antagonist dl-2-amino-5-phosphonovalerate significantly disrupted synaptic enhancement after associative training but did not disrupt synaptic enhancement after nonassociative training. Thus, classical conditioning in Aplysia appears to be mediated, in part, by LTP due to activation of NMDA-related receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Murphy, G G -- Glanzman, D L -- F31-MH11136/MH/NIMH NIH HHS/ -- NS29563/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1997 Oct 17;278(5337):467-71.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Interdepartmental Graduate Program in Neuroscience, School of Medicine, University of California, Los Angeles, CA 90095, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9334306" target="_blank"〉PubMed〈/a〉
Keywords:
2-Amino-5-phosphonovalerate/pharmacology
;
Animals
;
Aplysia
;
*Conditioning, Classical
;
Excitatory Amino Acid Antagonists/pharmacology
;
Excitatory Postsynaptic Potentials
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*Long-Term Potentiation/drug effects
;
Models, Neurological
;
Motor Neurons/drug effects/*physiology
;
Neurons, Afferent/drug effects/*physiology
;
Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors/metabolism
;
Serotonin/physiology
;
Synapses/drug effects/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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