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  • 1
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    Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan (2011)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2011-04-01
    Description: Genetic studies indicate that protein homeostasis is a major contributor to metazoan longevity. Collapse of protein homeostasis results in protein misfolding cascades and the accumulation of insoluble protein fibrils and aggregates, such as amyloids. A group of small molecules, traditionally used in histopathology to stain amyloid in tissues, bind protein fibrils and slow aggregation in vitro and in cell culture. We proposed that treating animals with such compounds would promote protein homeostasis in vivo and increase longevity. Here we show that exposure of adult Caenorhabditis elegans to the amyloid-binding dye Thioflavin T (ThT) resulted in a profoundly extended lifespan and slowed ageing. ThT also suppressed pathological features of mutant metastable proteins and human beta-amyloid-associated toxicity. These beneficial effects of ThT depend on the protein homeostasis network regulator heat shock factor 1 (HSF-1), the stress resistance and longevity transcription factor SKN-1, molecular chaperones, autophagy and proteosomal functions. Our results demonstrate that pharmacological maintenance of the protein homeostatic network has a profound impact on ageing rates, prompting the development of novel therapeutic interventions against ageing and age-related diseases.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610427/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610427/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alavez, Silvestre -- Vantipalli, Maithili C -- Zucker, David J S -- Klang, Ida M -- Lithgow, Gordon J -- 1R01AG029631-01A1/AG/NIA NIH HHS/ -- AG029631-01A1/AG/NIA NIH HHS/ -- AG21069/AG/NIA NIH HHS/ -- AG22868/AG/NIA NIH HHS/ -- ES016655/ES/NIEHS NIH HHS/ -- R01 AG021069/AG/NIA NIH HHS/ -- R01 AG022868/AG/NIA NIH HHS/ -- R01 AG029631/AG/NIA NIH HHS/ -- RL1 ES016655/ES/NIEHS NIH HHS/ -- U19AG0231222/AG/NIA NIH HHS/ -- UL1 RR024917/RR/NCRR NIH HHS/ -- England -- Nature. 2011 Apr 14;472(7342):226-9. doi: 10.1038/nature09873. Epub 2011 Mar 30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, California 94945, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21451522" target="_blank"〉PubMed〈/a〉
    Keywords: Aging/*drug effects/metabolism/pathology ; Amyloid/*metabolism ; Amyloid beta-Peptides/antagonists & inhibitors/genetics/metabolism/toxicity ; Animals ; Autophagy ; Caenorhabditis elegans/drug effects/*metabolism/physiology ; Caenorhabditis elegans Proteins/metabolism ; Curcumin/pharmacology ; DNA-Binding Proteins/metabolism ; Dose-Response Relationship, Drug ; Forkhead Transcription Factors ; Homeostasis/*drug effects ; Humans ; Longevity/*drug effects/physiology ; Molecular Chaperones/metabolism ; Paralysis/drug therapy ; Phenotype ; Proteasome Endopeptidase Complex/metabolism ; Protein Binding/drug effects ; Proteins/*metabolism ; Survival Analysis ; Thiazoles/metabolism/*pharmacology ; Transcription Factors/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 2
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    The GALAH survey: the data reduction pipeline (2016)
    Oxford University Press
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    Publication Date: 2016-10-27
    Description: We present the data reduction procedures being used by the GALactic Archeology with Hermes (GALAH) survey, carried out with the HERMES fibre-fed, multi-object spectrograph on the 3.9-m Anglo-Australian Telescope. GALAH is a unique survey, targeting 1 million stars brighter than magnitude V = 14 at a resolution of 28 000 with a goal to measure the abundances of 29 elements. Such a large number of high-resolution spectra necessitate the development of a reduction pipeline optimized for speed, accuracy, and consistency. We outline the design and structure of the iraf -based reduction pipeline that we developed, specifically for GALAH, to produce fully calibrated spectra aimed for subsequent stellar atmospheric parameter estimation. The pipeline takes advantage of existing iraf routines and other readily available software so as to be simple to maintain, testable, and reliable. A radial velocity and stellar atmospheric parameter estimator code is also presented, which is used for further data analysis and yields a useful verification of the reduction quality. We have used this estimator to quantify the data quality of GALAH for fibre cross-talk level (0.5 per cent) and scattered light (~5 counts in a typical 20 min exposure), resolution across the field, sky spectrum properties, wavelength solution reliability (better than 1 km s –1 accuracy), and radial velocity precision.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press
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  • 3
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    The GALAH survey: observational overview and Gaia DR1 companion (2016)
    Oxford University Press
    Details
    Publication Date: 2016-12-18
    Description: The Galactic Archaeology with HERMES (GALAH) survey is a massive observational project to trace the Milky Way's history of star formation, chemical enrichment, stellar migration and minor mergers. Using high-resolution ( R ~= 28 000) spectra, taken with the High Efficiency and Resolution Multi-Element Spectrograph (HERMES) instrument at the Anglo-Australian Telescope, GALAH will determine stellar parameters and abundances of up to 29 elements for up to one million stars. Selecting targets from a colour-unbiased catalogue built from 2MASS, APASS and UCAC4 data, we expect to observe dwarfs at 0.3–3 kpc and giants at 1–10 kpc. This enables a thorough local chemical inventory of the Galactic thin and thick discs, and also captures smaller samples of the bulge and halo. In this paper, we present the plan, process and progress as of early 2016 for GALAH survey observations. In our first two years of survey observing we have accumulated the largest high-quality spectroscopic data set at this resolution, over 200 000 stars. We also present the first public GALAH data catalogue: stellar parameters ( T eff , log( g ), [Fe/H], [α/Fe]), radial velocity, distance modulus and reddening for 10 680 observations of 9860 Tycho-2 stars, 7894 of which are included in the first Gaia data release.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press
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