Publication Date:
1982-01-22
Description:
Extrathyroidal tissues of man and the rat contain a potent inhibitor of the binding of thyroid hormones to serum proteins and to an anion-exchange resin. The inhibitor is heat-labile and nondialyzable. It acts by reducing the binding affinity of thyroid hormones to serum proteins, not by reducing the number of binding sites. The tissue inhibitor is similar in several characteristics to an inhibitor described previously in the serum of some critically ill patients, suggesting that the tissue inhibitor may leak into the circulation in severe illnesses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chopra, I J -- Solomon, D H -- Teco, G N -- Eisenberg, J B -- AM 16155/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 22;215(4531):407-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7058324" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
*Antithyroid Agents
;
Blood Proteins/*metabolism
;
Humans
;
Male
;
Protein Binding/drug effects
;
Rats
;
Thyroxine/*metabolism
;
Tissue Distribution
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink