Publication Date:
1994-07-22
Description:
Repeat tracts of guanine bases found in DNA and RNA can form tetraplex structures in the presence of a variety of monovalent cations. Evidence suggests that guanine tetraplexes assume important functions within chromosomal telomeres, immunoglobulin switch regions, and the human immunodeficiency virus genome. The structure of a parallel-stranded tetraplex formed by the hexanucleotide d(TG4T) and stabilized by sodium cations was determined by x-ray crystallography to 1.2 angstroms resolution. Sharply resolved sodium cations were found between and within planes of hydrogen-bonded guanine quartets, and an ordered groove hydration was observed. Distinct intra- and intermolecular stacking arrangements were adopted by the guanine quartets. Thymine bases were exclusively involved in making extensive lattice contacts.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Laughlan, G -- Murchie, A I -- Norman, D G -- Moore, M H -- Moody, P C -- Lilley, D M -- Luisi, B -- New York, N.Y. -- Science. 1994 Jul 22;265(5171):520-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Medical Research Council Virology Unit, University of Glasgow, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8036494" target="_blank"〉PubMed〈/a〉
Keywords:
Computer Graphics
;
Crystallization
;
Crystallography, X-Ray
;
Guanine/*chemistry
;
Hydrogen Bonding
;
Molecular Structure
;
*Nucleic Acid Conformation
;
Oligodeoxyribonucleotides/*chemistry
;
Sodium
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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