Publication Date:
2011-10-29
Description:
Innate lymphoid cells (ILC) expressing the transcription factor RORgammat induce the postnatal formation of intestinal lymphoid follicles and regulate intestinal homeostasis. RORgammat(+) ILC express the aryl hydrocarbon receptor (AhR), a highly conserved, ligand-inducible transcription factor believed to control adaptation of multicellular organisms to environmental challenges. We show that AhR is required for the postnatal expansion of intestinal RORgammat(+) ILC and the formation of intestinal lymphoid follicles. AhR activity within RORgammat(+) ILC could be induced by dietary ligands such as those contained in vegetables of the family Brassicaceae. AhR-deficient mice were highly susceptible to infection with Citrobacter rodentium, a mouse model for attaching and effacing infections. Our results establish a molecular link between nutrients and the formation of immune system components required to maintain intestinal homeostasis and resistance to infections.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kiss, Elina A -- Vonarbourg, Cedric -- Kopfmann, Stefanie -- Hobeika, Elias -- Finke, Daniela -- Esser, Charlotte -- Diefenbach, Andreas -- New York, N.Y. -- Science. 2011 Dec 16;334(6062):1561-5. doi: 10.1126/science.1214914. Epub 2011 Oct 27.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Medical Microbiology and Hygiene, University of Freiburg Medical Center, Freiburg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22033518" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Basic Helix-Loop-Helix Transcription Factors/deficiency/genetics/*metabolism
;
Cell Line, Tumor
;
Citrobacter rodentium/immunology
;
Diet
;
Enterobacteriaceae Infections/immunology
;
Intestine, Small/*cytology/immunology
;
Ligands
;
Lymphocytes/immunology/*metabolism
;
Mice
;
Mice, Inbred C57BL
;
Organogenesis
;
Receptors, Aryl Hydrocarbon/deficiency/genetics/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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