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  • 1
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    Redundant Logic Insertion and Latency Reduction in Self-Timed Adders (2013)
    Hindawi
    Details
    Publication Date: 2013-02-26
    Description: A novel concept of logic redundancy insertion is presented that facilitates significant latency reduction in self-timed adder circuits. The proposed concept is universal in the sense that it can be extended to a variety of self-timed design methods. Redundant logic can be incorporated to generate efficient self-timed realizations of iterative logic specifications. Based on the case study of a 32-bit self-timed carry-ripple adder, it has been found that redundant implementations minimize the data path latency by 21.1% at the expense of increases in area and power by 2.3% and 0.8% on average compared to their nonredundant counterparts. However, when considering further peephole logic optimizations, it has been observed in a specific scenario that the delay reduction could be as high as 31% while accompanied by only meager area and power penalties of 0.6% and 1.2%, respectively. Moreover, redundant logic adders pave the way for spacer propagation in constant time and garner actual case latency for addition of valid data.
    Print ISSN: 1065-514X
    Electronic ISSN: 1563-5171
    Topics: Electrical Engineering, Measurement and Control Technology
    Published by Hindawi
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  • 2
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    Anti-CotH3 antibodies protect mice from mucormycosis by prevention of invasion and augmenting opsonophagocytosis (2019)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2019
    Description: 〈p〉Mucorales are fungal pathogens that cause mucormycosis, a lethal angioinvasive disease. Previously, we demonstrated that 〈i〉Rhizopus〈/i〉, the most common cause of mucormycosis, invades endothelial cells by binding of its CotH proteins to the host receptor GRP78. Loss of CotH3 renders the fungus noninvasive and attenuates 〈i〉Rhizopus〈/i〉 virulence in mice. Here, we demonstrate that polyclonal antibodies raised against peptides of CotH3 protected diabetic ketoacidotic (DKA) and neutropenic mice from mucormycosis compared to mice treated with control preimmune serum. Passive immunization with anti-CotH3 antibodies enhanced neutrophil inlfux and triggered Fc receptor-mediated enhanced opsonophagocytosis killing of 〈i〉Rhizopus delemar〈/i〉. Monoclonal antibodies raised against the CotH3 peptide also protected immunosuppressed mice from mucormycosis caused by 〈i〉R. delemar〈/i〉 and other Mucorales and acted synergistically with antifungal drugs in protecting DKA mice from 〈i〉R. delemar〈/i〉 infection. These data identify anti-CotH3 antibodies as a promising adjunctive immunotherapeutic option against a deadly disease that often poses a therapeutic challenge.〈/p〉
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Large porous particles for pulmonary drug delivery (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-06-20
    Description: A new type of inhalation aerosol, characterized by particles of small mass density and large size, permitted the highly efficient delivery of inhaled therapeutics into the systemic circulation. Particles with mass densities less than 0.4 gram per cubic centimeter and mean diameters exceeding 5 micrometers were inspired deep into the lungs and escaped the lungs' natural clearance mechanisms until the inhaled particles delivered their therapeutic payload. Inhalation of large porous insulin particles resulted in elevated systemic levels of insulin and suppressed systemic glucose levels for 96 hours, whereas small nonporous insulin particles had this effect for only 4 hours. High systemic bioavailability of testosterone was also achieved by inhalation delivery of porous particles with a mean diameter (20 micrometers) approximately 10 times that of conventional inhaled therapeutic particles.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Edwards, D A -- Hanes, J -- Caponetti, G -- Hrkach, J -- Ben-Jebria, A -- Eskew, M L -- Mintzes, J -- Deaver, D -- Lotan, N -- Langer, R -- GM26698/GM/NIGMS NIH HHS/ -- HD29125/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1997 Jun 20;276(5320):1868-71.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemical Engineering, Pennsylvania State University, 204 Fenske Laboratory, University Park, PA 16802, USA. dxe11@psuv.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9188534" target="_blank"〉PubMed〈/a〉
    Keywords: *Administration, Inhalation ; Aerosols ; Animals ; Biological Availability ; Blood Glucose/analysis ; Bronchoalveolar Lavage ; *Drug Carriers ; Drug Compounding ; Insulin/administration & dosage/blood/pharmacokinetics ; *Lactic Acid ; *Lung ; Male ; Particle Size ; *Polyglycolic Acid ; *Polylysine ; *Polymers ; Rats ; Rats, Sprague-Dawley ; Testosterone/administration & dosage/blood/pharmacokinetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
    Electronic Resource
    Electronic Resource
    The influence of Reynolds number upon the apparent permeability of spatially periodic arrays of cylinders (1990)
    New York, NY : American Institute of Physics (AIP)
    Physics of Fluids 2 (1990), S. 45-55 
    Details
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Flow fields within spatially periodic arrays of cylinders arranged in square and hexagonal lattices are calculated, with microscale Reynolds number ranging between zero and 200, employing a finite element numerical scheme. The terminology of an "apparent permeability'' is introduced to establish a relationship existing between mean velocity and macroscopic pressure gradient characterized by a finite Reynolds number flow. In contrast with the low Reynolds number "true '' permeability, the apparent permeability is shown here to generally depend upon the direction of the applied pressure gradient, owing to nonlinearities existing within the local fluid motion. The orientation-dependent permeabilities of both square and hexagonal monodisperse arrays are observed to diminish with increasing Reynolds number. Similar behavior is also observed for a bidisperse square array, though the apparent permeability of the latter is shown less sensitive to Darcy velocity orientation at large Reynolds numbers in comparison to the corresponding monodisperse square array, for all cylinder concentrations examined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.857691
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  • 5
    Electronic Resource
    Electronic Resource
    Oxochloro complexes of rhenium(VI) (1968)
    s.l. : American Chemical Society
    Inorganic chemistry 7 (1968), S. 1898-1903 
    Details
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ic50067a041
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  • 6
    Electronic Resource
    Electronic Resource
    Conversion of the molybdenum(III) halides to metal-metal bonded dimers of the type Mo2X4L4 by dimethylamine and tertiary phosphines (1979)
    s.l. : American Chemical Society
    Inorganic chemistry 18 (1979), S. 1172-1174 
    Details
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ic50194a057
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  • 7
    Electronic Resource
    Electronic Resource
    MATHEMATICAL MODELS IN AGRICULTURE (Book). (1984)
    Oxford, UK : Blackwell Publishing
    Plant, cell & environment 7 (1984), S. 0 
    Details
    ISSN: 1365-3040
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/1365-3040.ep11592209
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  • 8
    Electronic Resource
    Electronic Resource
    Light interception by grain legume row crops (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Plant, cell & environment 7 (1984), S. 0 
    Details
    ISSN: 1365-3040
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Abstract. Four contrasting grain legume species (Glycine max, Vigna radiata. Vigna mungo and Vigna angularis) were grown as row crops with both 0.5 m and 1.0 m spacings between row centres. Light transmission profiles, at ground level, across rows of plants, were obtained for each crop on a number of occasions during growth. The proportion of the incident downward light flux density intercepted by each crop at solar noon was found to be simply and directly related to the product of the proportion of the ground area covered by the crop's leaf canopy and the proportion of the downward light flux density incident at the row centre that was intercepted by the crop. The average proportion of the incident light energy intercepted over the whole day could be related to the proportion intercepted at solar noon.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/1365-3040.ep11589442
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  • 9
    Electronic Resource
    Electronic Resource
    On experimental reflected density currents and the interpretation of certain turbidites (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Sedimentology 41 (1994), S. 0 
    Details
    ISSN: 1365-3091
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: Experimental results are reported concerning the nature of reflected flows generated when density currents are incident upon ramp-type flow obstructions. The reflected flows are bores (moving hydraulic jumps that transport mass) with flow characteristics in common with either a group of solitary waves (weak Type A bores) or the original density current (strong Type C bores). Alternatively, the bore may have attributes in common with both of these end-member forms (intermediate Type B bores). Bore strength is positively correlated with the ratio of reverse flow thickness to that of the residual tail of the forward flow. The largest values of this ratio occur when ‘proximal’reflections arrive at the steeper ramps. Measured particle paths in the bores indicate that natural examples will have the potential to transport and deposit sediment. Strong bores have velocity characteristics very similar to the original current and thus in nature the generated sequence of sedimentary structures will resemble those of the original depositing current. The train of solitary waves that make up a weak bore sequence exhibits a pulsating velocity profile at a point. Such flows may thus generate repeated sequences of structures separated by fine ‘drapes’that are distinguishable from the deposits of the original turbidity current. These conclusions are applied to examples of reflected turbidites described from the Palaeozoic to Quaternary sedimentary record.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3091.1994.tb02005.x
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  • 10
    Electronic Resource
    Electronic Resource
    Acetatobis(triphenylphosphine)copper(I) (1975)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 31 (1975), S. 2695-2697 
    Details
    ISSN: 1600-5740
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0567740875008527
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