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  • 1
    Publication Date: 2001-05-01
    Print ISSN: 1369-7021
    Electronic ISSN: 1873-4103
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by Elsevier
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  • 2
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 416 (2002), S. 274-275 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Within a nerve cell, or neuron, differences in electrical potential encode information, and messages can be passed on to other neurons through connections that may be chemical or electrical. But, like nineteenth-century linguists contemplating the hieroglyphs of the Rosetta Stone, we have only ...
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Advances in science and technology Vol. 53 (Oct. 2006), p. 107-115 
    ISSN: 1662-0356
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Natural Sciences in General , Technology
    Notes: Bionanotechnology has seen much interest in the past few years. The development innew nanotechnologies and the transfer of such to biomedical applications has been received withlarge expectations. Here we will describe some of the most common techniques to prepare surfaceswith nanometric sized features and how they have been applied to control cell behavior. The focus,however, will be on electron beam lithography and its use in biological applications. We will showthat such highly ordered surfaces exhibit low adhesive properties for cells. Also, such topographieschange the wetting properties to be either more hydrophilic or hydrophobic depending on thesurface energy of the flat surface. Today, little research has found its way to the commercial market.This is mainly down to the ability to make large areas or large quantities of nano patternedmaterials. We will describe a few methods by which we think it would be possible to mass producenano topographically patterned surfaces
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Experimental biology online 1 (1997), S. 1-13 
    ISSN: 1430-3418
    Keywords: Neurite ; neurotrophin ; activation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Laminin, neural cell adhesion molecule (N-CAM) and the neurotrophins, ciliary neurotrophic factor (CNTF) and brain-derived neurotrophic factor (BDNF) play important roles in the formation and maintenance of the axons and dendrites of vertebrate neurons. The conventional explanation of the action of N-CAM and laminin has been that they provide suitable substrata on which the cells can adhere, spread and extend. We show by applying these molecules immobilised to small beads (tethered) that they activate adhesion and cell extension on substrata where no special adhesion molecules have been placed. This activation occurs even when the beads are attached to the side of the cell not in contact with the substratum, implying that the signal is transduced to activate parts of the cell remote from the vicinity of the bead.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1430-3418
    Keywords: Nerve cell ; Microelectronics ; Development ; Regeneration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Nerve cell growth is influenced by guiding properties of its substratum. Microfabricated cell culture substrata were used to determine whether rat dorsal root ganglia (DRG) nerve cells could detect and integrate simultaneous model adhesive and topographic guidance cues. Interference reflection microscopy demonstrated strips of surface contact under the marginal zone of growth cones on planar surfaces which were coincident with actin immunostaining at the periphery of the C-domain. Clusters of focal contacts below the growth cone C-domain delineated the track edges on adhesive gratings. Neurite extension was guided most effectively by adhesive gratings of 25-μm period where highly aligned cells were typically bipolar. Nanometric steps and differences in surface texture between the adhesive tracks was detected using atomic force microscopy (AFM). Neurites did not align to 12- to 100-μm pitch grooves which were less than 1 μm deep. The proportion of aligned neurites increased with groove depth. Maximum neurite alignment was seen when 6-μm-deep, 25-μm-wide grooves contained superimposed parallel adhesive tracks of matched pitch. Neurites aligned preferentially to adhesive tracks superimposed orthogonally over shallow grooves (1 μm deep). Primary neurites aligned increasingly to grooves with orthogonal adhesive tracks as their depth increased. These neurites frequently had highly branched terminal arbours aligned to the orthogonal adhesive tracks. We conclude that morphogenetic guidance cues can interact synergistically and hierarchically to steer nerve cell growth.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Experimental biology online 3 (1998), S. 1-15 
    ISSN: 1430-3418
    Keywords: Bone ; Cell behaviour ; Chondrocyte ; Endothelia ; Epitenon
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The motile behaviour, growth and reactions of osteoblasts, chondrocytes, epitenal cells and endothelia to culture on extended concave surfaces inside tubes is reported. Time-lapse video observations show that these cells can be successfully grown in quartz tubes for up to 21days. The cells would attach to the concave surfaces even when the radius of curvature was as low as 25 μm. The cells attached to the walls were not oriented. As culturing progressed the chondrocytes, osteoblasts and epitenon cells tended to detach from the walls of the tubes, forming long cords of cells attached to the walls at a few points only. Endothelial cells did not detach. These cords showed extensive lamellipodial activity at their points of attachment to the tube wall. The cells in these cords do not show contact inhibition of movement.
    Type of Medium: Electronic Resource
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  • 7
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    Arizona Board of Regents | Marine Biological Laboratory Archives (Woods Hole, Mass.)
    In:  The John Philip Trinkaus Papers, Box 4, Folder 19, Marine Biological Laboratory Archives
    Publication Date: 2023-01-12
    Description: Letter to Trinkaus, thanking him for sending reprints.
    Description: Typed letter
    Description: 1-page
    Description: Correspondence
    Keywords: People
    Repository Name: Woods Hole Open Access Server
    Language: English
    Type: Text
    Format: Text
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  • 8
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    Arizona Board of Regents | Marine Biological Laboratory Archives (Woods Hole, Mass.)
    In:  The John Philip Trinkaus Papers, Box 7, Folder 6, Marine Biological Laboratory Archives
    Publication Date: 2023-01-12
    Description: Letter to Tickle, asking her to get a reference from Trinkaus.
    Description: Typed letter
    Description: 1-page
    Description: Correspondence
    Keywords: People
    Repository Name: Woods Hole Open Access Server
    Language: English
    Type: Text
    Format: Text
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  • 9
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    Arizona Board of Regents | Marine Biological Laboratory Archives (Woods Hole, Mass.)
    In:  The John Philip Trinkaus Papers, Box 7, Folder 6, Marine Biological Laboratory Archives
    Publication Date: 2023-01-12
    Description: Letter of recommendation for Cheryll Tickle.
    Description: Typed letter
    Description: 1-page
    Description: Text
    Keywords: People
    Repository Name: Woods Hole Open Access Server
    Language: English
    Type: Text
    Format: Text
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  • 10
    facet.materialart.
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    Arizona Board of Regents | Marine Biological Laboratory Archives (Woods Hole, Mass.)
    In:  The John Philip Trinkaus Papers, Box 4, Folder 19, Marine Biological Laboratory Archives
    Publication Date: 2023-01-12
    Description: Letter to Trinkaus about a possible symposium volume for Michael Abercrobie's 70th birthday.
    Description: Typed letter
    Description: 1-page
    Description: Correspondence
    Keywords: People ; Publications
    Repository Name: Woods Hole Open Access Server
    Language: English
    Type: Text
    Format: Image/tif
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