Publikationsdatum:
2017-09-13
Beschreibung:
Ewing sarcoma usually expresses the EWS/FLI fusion transcription factor oncoprotein. EWS/FLI regulates myriad genes required for Ewing sarcoma development. EWS/FLI binds GGAA-microsatellite sequences in vivo and in vitro. These sequences provide EWS/FLI-mediated activation to reporter constructs, suggesting that they function as EWS/FLI-response elements. We now demonstrate the critical role of...
Print ISSN:
0027-8424
Digitale ISSN:
1091-6490
Thema:
Biologie
,
Medizin
,
Allgemeine Naturwissenschaft
Permalink