ISSN:
1432-1041
Keywords:
bufurlol
;
pharmacokinetics
;
oxidative polymorphism
;
hydroxylation polymorphism
;
betaadrenoceptor blocking agents
;
phenotype
;
interindividual variations
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The oxidative metabolism of bufuralol is under the same genetic control as that of debrisoquine and sparteine. 154 fasting volunteers received a 30 mg tablet of bufuralol and a blood sample was taken 3 h later. In poor metabolizers (8% of the sample) the plasma bufuralol concentrations were very high and the metabolite concentrations were low. The genetic oxidative status is a major source of interindividual variation in the plasma concentration of drugs that undergo oxidative metabolism.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00607090
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