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  • 1
    Electronic Resource
    Electronic Resource
    Role of growth hormone in experimental phosphorus deprivation in the rat (1980)
    Springer
    Calcified tissue international 32 (1980), S. 105-112 
    Details
    ISSN: 1432-0827
    Keywords: Rat ; Hypophysectomy ; Dietary phosphorus deprivation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The demands of growth are known to exacerbate the effect of phosphorus deprivation (PD). We examined whether changes associated with PD could be prevented in young rats in which growth and growth hormone (GH) were eliminated by hypophysectomy (HPX) and whether PD in normal intact rats (INT) was associated with increased secretion of GH. INT or thyroxine- and ACTH-replaced HPX rats were fed one of the three diets: 0.31% P (NP); 0.027% P (LP), and 0.31% P, pair-fed with LP-mates (NP-PF). The results indicate that HPX did not qualitatively alter several physiologic responses to PD: (a) serum and urinary phosphorus (P) decreased and urinary calcium (Ca) increased; (b) net intestinal Ca retention fell and duodenal sac uptake of45Ca rose; and (c) external P balance was restored and duodenal sac uptake of32P-phosphate increased. Only the hypercalcemia seen in INT, LP rats was prevented by HPX. In INT rats serum immunoassayable GH levels, measured in single samples, were not different between different dietary groups while pituitary bioassayable GH was reduced in both LP and NP-PF rats when compared to the NP rats. Thus, except for hypercalcemia, the physiologic responses associated with PD are not prevented by the elimination of growth and GH, and the development of these responses in INT rats was not associated with a consistent or specific alteration in GH secretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02408529
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    Paper (German National Licenses)
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  • 2
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    Metabolic Balance Study of Plasmapheresis in a Case of Waldenström’s Macroglobulinemia (1962)
    American Society of Hematology
    Details
    Publication Date: 1962-04-01
    Description: A metabolic balance study was undertaken to evaluate the results of plasmapheresis in a case of Waldenström’s macroglobulinemia with an associated cryoglobulinemia. Balances of nitrogen, P, Ca, Cl, and Na and K were carried out. Additional observations were made on serum and urinary protein and uric acid. After a control period of 15 days, the subject was bled 500 cc. per day for 15 days. The plasma was separated by centrifugation and erythrocytes reinfused. A total of 500 Gm. of protein in 5,700 cc. of plasma were removed by this technic. A final control period was continued for 10 days. Plasmapheresis was observed to lower the abnormal plasma protein fraction from 7.5 Gm. per cent to 4.5 Gm. per cent whereas the concentrations of the other plasma proteins remained unchanged. By the last day of the final control period, however, the abnormal protein concentration had risen to preplasmapheresis levels. The patient’s pronounced retinal venous dilatation and "sausage" segmentation were less marked at the end of the plasmapheresis period. The negative nitrogen balance during plasmapheresis was rapidly counteracted by diminished urinary nitrogen excretion. At the same time, urinary protein excretion also fell. Na and Cl urinary excretion responded similarly to that of nitrogen. P and K balances were slightly negative during plasmapheresis, probably reflecting tissue breakdown. Ca balance remained in equilibrium and urinary uric acid levels were unchanged. The study demonstrated that the elevated plasma paraprotein levels in a case of Waldenström’s macroglobulinemia may be lowered by plasmapheresis. Preplasmapheresis levels were rapidly reestablished following discontinuance of the procedure.
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
    Published by American Society of Hematology
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