ISSN:
1420-9071
Keywords:
Amylin
;
gastric emptying
;
intestinal transit
;
neostigmine
;
domperidone
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract The effect of rat amylin on gastric emptying and intestinal transit in the rat was examined. Amylin administered intracerebroventricularly (1, 2, 2.5 or 4 μg/rat) produced the maximal decrease in gastric emptying and intestinal transit at the dose of 2.5 μg/rat. Higher doses produced a lower effect. Peripheral administration (25, 50 or 100 μg/kg) produced dose-dependent effects. Pre-treatment with neostigmine blocked the effect of amylin when it was centrally injected, while the effect of amylin given peripherally was partially reduced. Pre-treatment with domperidone decreased the inhibitory effect of peripherally injected amylin, but no effect was observed when the peptide was centrally injected.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01925572
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