ISSN:
1573-6865
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary The ultrastructural localization of four acid hydrolases (acid phosphatase, β-glucuronidase, β-glucosaminidase and α-naphthylacetate esterase) has been studied in lymphocytes from 16 patients with three types of chronic T-cell leukaemia, namely, T-prolymphocytic leukaemia (T-PLL), T-chronic lymphocytic leukaemia (T-CLL) and adult T-cell lymphoma leukaemia (ATLL). Different patterns of enzyme distribution were observed in the leukaemic T-cells from these disorders. In T-PLL, reactivity for the four acid hydrolases was confined to single or a few large granules. Gall bodies were reactive for β-glucuronidase, β-glucosaminidase and α-naphthylacetate esterase but apparently unreactive for acid phosphatase. In T-CLL, scattered small-to medium-size cytoplasmic granules and many parallel tubular arrays were strongly reactive for acid phosphatase, β-glucuronidase and β-glucosidase but showed no reactivity for α-naphthylacetate esterase. Intermediate features were observed in ATLL. The observed differences in enzyme reactivity reflect a different content of lysosomal granules in the various types of leukaemic T-cells. They also suggest that similar differences may be found in normal T-lymphocyte subsets.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01011828
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