ISSN:
1662-0356
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Natural Sciences in General
,
Technology
Notes:
Injected, nano-scale drug delivery systems, or nanovectors, are ideal candidates toprovide breakthrough solutions to the time-honored problem of optimizing therapeutic index for atreatment. Even modest amounts of progress towards this goal have historically engenderedsubstantial benefits across multiple fields of medicine, with the translability, for example, fromoncology to infectious diseases being granted by the fact that the progresses had a single commondenominator in the underlying technological platform. In this work we combine multiscalemolecular modeling and experimental approaches to define the mode and the molecularrequirements of the interaction of oligonucleotide-based therapeutics (e.g., small interfering(si)RNA) and dendrimeric delivery reagents. In details, by mimicking in silico the experimentsperformed in vitro, information at the molecular level (e.g., interaction forces, mechanisms,structures, free energies of binding, self-assembly, etc.), which cannot be accessed by otherexperimental techniques, are obtained. Thus, critical molecular parameters for optimizing and denovo designing nanocargos for tissues and tumor specific uptake can be determined. This wouldprovide valuable information to devise optimal delivery modalities that would increase the efficacyof siRNA therapeutics in cells and laboratory animals and move them toward clinical applications
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/42/transtech_doi~10.4028%252Fwww.scientific.net%252FAST.57.154.pdf
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