ISSN:
1573-4919
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
Notes:
Summary We have observed a close relationship between polyamines (spermine and spermidine) and nucleic acids in connection with myocardial hypertrophy obtained by aortic constriction or by physical exercise. The role of spermine in RNA synthesis has been investigated on perfused heart, and we have observed a rapid increase of ribose-5-3H incorporation into RNA subcellular fractions. With the same experimental conditions we have considered the action of spermine on histone acetylation. The arginine-rich fractions are more acetylated under the action of spermine. This finding indicates a positive action of spermine on gene derepression mechanism.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01659187
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