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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 86 (1964), S. 288-288 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of organic chemistry 38 (1973), S. 1047-1047 
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Macromolecules 6 (1973), S. 492-495 
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of organic chemistry 28 (1963), S. 3124-3129 
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 59 (1937), S. 1924-1931 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 13 (1978), S. 393-399 
    ISSN: 1432-1041
    Keywords: Oral mexiletine ; plasma concentrations ; absorption ; myocardial infarction ; ventricular arrhythmias
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In a preliminary study of mexiletine absorption in Coronary Care Unit patients with myocardial infarction, plasma mexiletine concentrations were significantly lower in those given narcotic analgesics. 166 patients then entered a comparative study of the effects of mexiletine and placebo on the incidence of ventricular arrhythmias after myocardial infarction (MI). Eighty-two patients were given mexiletine, 51 with MI. Mexiletine absorption was impaired in patients with MI and 66% failed to reach the minimum therapeutic plasma concentration of 1 µg/ml in 3 h. On the second and third hospital days, 34% and 25% respectively had subtherapeutic levels. In patients without MI, low plasma mexiletine concentrations were associated with the use of narcotic analgesics. The incidence of serious ventricular arrhythmias (VF, VT, R on T ectopic beats) was significantly lower in patients given mexiletine, and after 3 h most arrhythmias in this group occurred in patients with subtherapeutic mexiletine concentrations. Therapeutic failure of oral antiarrhythmic drugs soon after MI may be due to impaired absorption.
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Colloid & polymer science 256 (1978), S. 719-719 
    ISSN: 1435-1536
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 180 (1979), S. 633-647 
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Bromodifluoroacetaldehyde (5) was prepared from methyl bromodifluoroacetate (4) by reduction with lithium aluminium hydride. 4 was in turn prepared by bromination of chlorotrifluoroethylene (1) and treatment of the resulting 1,2-dibromo-1-chlorotrifluoroethane (2) with fuming H2SO4 and HgO. 5, properly purified, could be polymerized with anionic and cationic initiators to poly[oxy-2-(bromodifluoro)ethylidene] (12). Certain initiators produce partially or entirely amorphous soluble 12 of relatively low molecular weight. Most polymers, however, are insoluble, crystalline, and presumably isotactic. Thermal vacuum degradation of the polymers 12 gave monomer 5 in essentially quantitative yield. The thermal stability of polymers can significantly be improved by endcapping or treating with agents which replace unstable end groups. The ceiling temperature of the polymerization of 5 was determined to be +48°C. 5 was copolymerized with trichloroacetaldehyde with cationic or anionic initiators to copolymers containing predominantly units of 5. 5 could also be copolymerized with phenyl isocyanate to a polymer containing oxycarbamido linkages.
    Additional Material: 9 Ill.
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Medical & biological engineering & computing 31 (1993), S. 111-117 
    ISSN: 1741-0444
    Keywords: Defibrillation ; Detection algorithm ; ECG monitoring ; Ventricular fibrillation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Four ventricular fibrillation (VF) detection techniques were assessed using recordings of VF to evaluate sensitivity and VF-like recordings to evaluate specificity. The recordings were obtained from Coronary Care Unit patients. The techniques were: threshold crossing intervals (TCl); peaks in the autocorrelation function (ACF); signal content outside the mean frequency (VF-filter); and signal spectrum shape (spectrum). Using 70 extracts, each 4 s long, from VF recordings, the VF filter achieved a sensitivity of 77 per cent; the ACF, TCl and spectrum algorithms had sensitivities of 67, 53 and 46 per cent, respectively. Susceptibility to false alarms was assessed using 40 extracts from VF-like recordings. The TCl algorithm was the most specific (93 per cent), while the spectrum, VF filter and ACF algorithms had specificities of 72, 55 and 38 per cent, respectively. The TCl algorithm achieved overall sensitivity of 93 per cent and specificity of 60 per cent. The spectrum, VF filter and ACF algorithms had overall sensitivities of 80, 93 and 87 per cent, and overall specificities of 60, 20 and 0 per cent, respectively.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Chemistry Edition 15 (1977), S. 1123-1135 
    ISSN: 0360-6376
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Chlorodifluoroacetaldehyde has been prepared by lithium aluminum hydride reduction of methyl chlorodifluoroacetate. Purified chlorodifluoroacetaldehyde was polymerized to crystalline, insoluble polychlorodifluoroacetaldehyde or to a mixture of amorphous polymer soluble in organic solvents and insoluble polymer, depending on polymerization conditions and type and amount of initiators. The polymer, particularly the soluble fraction, could be end-capped by acetylation to improve the thermal stability of the initially unstable polymer. The thermal degradation of polymer prepared by various techniques has been studied before and after acetylation and the stability was compared to that of other polyhaloacetaldehydes. Chlorodifluoroacetaldehyde was copolymerized with other haloacetaldehydes and with phenyl isocyanate.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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