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  • 1
    Electronic Resource
    Electronic Resource
    Non-rejoining DNA breaks and cell inactivation (reply) (1978)
    [s.l.] : Nature Publishing Group
    Nature 272 (1978), S. 380-380 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] RITTER ET AL. REPLY- Goodhead et al. state that the initial slope mechanism of cell killing is dominant only at low doses, so that high-dose, non-rejoining DNA strand break (NRB) data cannot be compared with it. Such a comparison can be made, however. According to the model, the initial slope, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/272380a0
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  • 2
    Electronic Resource
    Electronic Resource
    Membrane initiation of DNA synthesis (1977)
    [s.l.] : Nature Publishing Group
    Nature 270 (1977), S. 543-543 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] HOBART et al.} reported convincing autoradiograiphic evidence that DNA replication is initiated near or on the nuclear membrane in sea urchins. In their discussion of the difference between their results and those reported by others for mammalian cells2"4, they raise the possibility that the latter ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/270543a0
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  • 3
    Electronic Resource
    Electronic Resource
    Nucleosome structure controls rates of excision repair in DNA of human cells (1977)
    [s.l.] : Nature Publishing Group
    Nature 270 (1977), S. 451-453 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. 1 Repair replication in confluent human fibroblasts. Cultures were incubated in the presence of BUdr 105 M and FUdr 2x 106 M for 1 h, irradiated with 13 J m2 ultraviolet light and labelled for 2 h in BUdr 105 M, 3H-Tdr 10 uCi ml-1 (64 Ci mmol-1), FUdr 2x 106 M, hydroxyurea 2x 103 M; the DNA ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/270451a0
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  • 4
    Electronic Resource
    Electronic Resource
    High-LET radiations induce a large proportion of non-rejoining DNA breaks (1977)
    [s.l.] : Nature Publishing Group
    Nature 266 (1977), S. 653-655 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We measured DNA strand break induction and rejoining in Chinese hamster V79 S171 cells13. X rays (300 kVp, 1.6 mm Cu h.v.l.) and low-energy heavy ions from the Lawrence Berkeley Laboratory 88-inch cyclotron and heavy-ion linear accelerator provided radiations with the various LETs used (Table 1). ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/266653a0
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  • 5
    Electronic Resource
    Electronic Resource
    Cells have long experience of dealing with UVC light (2006)
    [s.l.] : Nature Publishing Group
    Nature 442 (2006), S. 244-244 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Sir In his News and Views article “Device physics: A bug-beating diode” (Nature 441, 299; 2006) describing the development of UVC-emitting diodes that promise to have major practical applications, Asif Khan states: “Earth's ozone ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/442244b
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  • 6
    Electronic Resource
    Electronic Resource
    DNA damage in the Antarctic (1991)
    [s.l.] : Nature Publishing Group
    Nature 350 (1991), S. 28-28 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR - The Antarctic ozone hole represents a cycle of annual springtime depletion of stratospheric ozone over the continent and surrounding ocean areas, with consequent increases in levels of ultraviolet-B radiation (UV-B, 280-320 nm)1. The ecological im-pact of this increased radiation is of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/350028b0
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  • 7
    Electronic Resource
    Electronic Resource
    The action of ultraviolet light on the patterns of banding induced by restriction endonucleases in human chromosomes (1984)
    Springer
    Chromosoma 90 (1984), S. 133-138 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The irradiation of metaphase spreads of human cells with ultraviolet (UV) light blocked the chromosome banding induced by Alu I, Mbo I, Dde I, Hinf I, Hae III, and Rsa I restriction endonucleases. At 13 J/m2 there was moderate inhibition of the nuclease action, which was detected as an increase in the stain intensity of chromosomes (Alu I, Mbo I, Dde I, Rsa I) or as a change in the banding pattern (Hinf I, Hae III). At 70–300 J/m2 the UV-induced blockage was complete; the chromosomes showed no banding, and stain intensity was similar to that of control slides incubated with buffer. — BrdU substitution and the irradiation of BrdU-substituted chromosomes with 313 nm light at 1800–15000 J/m2 did not block the action of restriction nucleases. On the other hand, UV irradiation of BrdU-substituted chromosomes inhibited the action of restriction enzymes at the same fluences that blocked the nuclease action in unsubstituted chromosomes. The data indicate that DNA-protein crosslinkage is the factor inhibiting DNA extraction and chromosome banding.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00292450
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  • 8
    Electronic Resource
    Electronic Resource
    Direct visualization of the sites of DNA methylation in human, and mosquito chromosomes (1986)
    Springer
    Chromosoma 94 (1986), S. 362-366 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Human and mosquito fixed chromosomes were digested with restriction endonucleases that are inhibited by the presence of 5-methylcytosine in their restriction sites (Hha I, Hin PI, Hpa II), and with endonucleases for which cleavage is less dependent on the state of methylation (Taq I, Msp I). Methylation-dependent enzymes extracted low DNA amounts from human chromosomes, while methylation-independent enzymes extracted moderate to high amounts of DNA. After DNA demethylation with 5-azacytidine the isoschizomers Hpa II (methylation-dependent) and Msp I (methylation-independent) extracted 12-fold and 1.4-fold amounts of DNA from human chromosomes, respectively. These findings indicate that human DNA has a high concentration of Hpa II and Msp I restriction sites (CCGG), and that the internal C of this sequence is methylated in most cases, while the external cytosine is methylated less often. All the enzymes tested released moderate amounts of DNA from mosquito chromosomes whether or not the DNA was demethylated with 5-azacytidine. Hpa II induced banding in the centromere chromosome regions. After demethylation with 5-azacytidine this banding disappeared. Mosquito DNA has therefore, moderate to high frequencies of nonmethylated CpG duplets. The only exception is the centromeric DNA, in which the high levels of C methylation present produce cleavage by Hpa II and the appearance of banding. Centromere regions of human chromosomes 1 have a moderately low concentration of Hpa II-Msp I restriction sites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00328636
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  • 9
    Electronic Resource
    Electronic Resource
    Cockayne syndrome complementation group B associated with xeroderma pigmentosum phenotype (1996)
    Springer
    Human genetics 〈Berlin〉 97 (1996), S. 176-179 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Two siblings have been reported whose clinical manifestations (cutaneous photosensitivity and central nervous system dysfunction) are strongly reminiscent of the DeSanctis-Cacchione syndrome (DCS) variant of xeroderma pigmentosum (XP), a severe form of XP. Fibroblasts from the siblings showed UV sensitivity, a failure of recovery of RNA synthesis (RRS) after UV-irradiation, and a normal level of unscheduled DNA synthesis (UDS), which were, unexpectedly, the biochemical characteristics usually associated with Cockayne syndrome (CS). However, no complementation group assignment in these cells has yet been performed. We here report that these patients can be assigned to CS complementation group B (CSB) by cell fusion complementation analysis. To our knowledge, these are the first patients with defects in the CSB gene to be associated with an XP phenotype. The results imply that the gene product from the CSB gene must interact with the gene products involved in excision repair and associated with XP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02265261
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  • 10
    Electronic Resource
    Electronic Resource
    Cockayne syndrome complementation group B associated with xeroderma pigmentosum phenotype (1996)
    Springer
    Human genetics 〈Berlin〉 97 (1996), S. 176-179 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Two siblings have been reported whose clinical manifestations (cutaneous photosensitivity and central nervous system dysfunction) are strongly reminiscent of the DeSanctis-Cacchione syndrome (DCS) variant of xeroderma pigmentosum (XP), a severe form of XP. Fibroblasts from the siblings showed UV sensitivity, a failure of recovery of RNA synthesis (RRS) after UV irradiation, and a normal level of unscheduled DNA synthesis (UDS), which were, unexpectedly, the biochemical characteristics usually associated with Cockayne syndrome (CS). However, no complementation group assignment in these cells has yet been performed. We here report that these patients can be assigned to CS complementation group B (CSB) by cell fusion complementation analysis. To our knowledge, these are the first patients with defects in the CSB gene to be associated with an XP phenotype. The results imply that the gene product from the CSB gene must interact with the gene products involved in excision repair and associated with XP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02265261
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