Publication Date:
2011-07-23
Description:
Microglia are highly motile phagocytic cells that infiltrate and take up residence in the developing brain, where they are thought to provide a surveillance and scavenging function. However, although microglia have been shown to engulf and clear damaged cellular debris after brain insult, it remains less clear what role microglia play in the uninjured brain. Here, we show that microglia actively engulf synaptic material and play a major role in synaptic pruning during postnatal development in mice. These findings link microglia surveillance to synaptic maturation and suggest that deficits in microglia function may contribute to synaptic abnormalities seen in some neurodevelopmental disorders.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Paolicelli, Rosa C -- Bolasco, Giulia -- Pagani, Francesca -- Maggi, Laura -- Scianni, Maria -- Panzanelli, Patrizia -- Giustetto, Maurizio -- Ferreira, Tiago Alves -- Guiducci, Eva -- Dumas, Laura -- Ragozzino, Davide -- Gross, Cornelius T -- New York, N.Y. -- Science. 2011 Sep 9;333(6048):1456-8. doi: 10.1126/science.1202529. Epub 2011 Jul 21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), Via Ramarini 32, 00015 Monterotondo, Italy.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21778362" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Brain/*growth & development/physiology
;
Chemokine CX3CL1/metabolism
;
Dendritic Spines/physiology/ultrastructure
;
Excitatory Postsynaptic Potentials
;
Guanylate Kinase/analysis
;
Hippocampus/*growth & development/*physiology
;
Long-Term Synaptic Depression
;
Membrane Proteins/analysis
;
Mice
;
Mice, Knockout
;
Microglia/*physiology
;
Miniature Postsynaptic Potentials
;
Neuronal Plasticity
;
Patch-Clamp Techniques
;
Pyramidal Cells/physiology
;
Receptors, Chemokine/genetics/metabolism
;
Receptors, Cytokine/genetics/metabolism
;
Receptors, HIV/genetics/metabolism
;
Signal Transduction
;
Synapses/*physiology
;
Synaptosomal-Associated Protein 25/analysis
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink