Publication Date:
2001-05-05
Description:
The COP9 signalosome is an evolutionary conserved multiprotein complex of unknown function that acts as a negative regulator of photomorphogenic seedling development in Arabidopsis. Here, we show that plants with reduced COP9 signalosome levels had decreased auxin response similar to loss-of-function mutants of the E3 ubiquitin ligase SCFTIR1. Furthermore, we found that the COP9 signalosome and SCFTIR1 interacted in vivo and that the COP9 signalosome was required for efficient degradation of PSIAA6, a candidate substrate of SCFTIR1. Thus, the COP9 signalosome may play an important role in mediating E3 ubiquitin ligase-mediated responses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schwechheimer, C -- Serino, G -- Callis, J -- Crosby, W L -- Lyapina, S -- Deshaies, R J -- Gray, W M -- Estelle, M -- Deng, X W -- New York, N.Y. -- Science. 2001 May 18;292(5520):1379-82. Epub 2001 May 3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11337587" target="_blank"〉PubMed〈/a〉
Keywords:
Arabidopsis/*drug effects/enzymology/genetics/growth & development
;
Brassica
;
Darkness
;
Gene Expression Regulation, Plant/drug effects
;
Genes, Reporter/genetics
;
Indoleacetic Acids/*pharmacology
;
Ligases/genetics/*metabolism
;
Multiprotein Complexes
;
Mutation/genetics
;
Peas
;
Peptide Hydrolases
;
Phenotype
;
Plant Proteins/genetics/*metabolism
;
Plant Roots/drug effects/enzymology/genetics/growth & development
;
Plants, Genetically Modified
;
Precipitin Tests
;
Protein Binding
;
Protein Biosynthesis
;
Protein Subunits
;
Proteins/genetics/*metabolism
;
RNA, Antisense/genetics
;
RNA, Plant/genetics/metabolism
;
Two-Hybrid System Techniques
;
Ubiquitin-Protein Ligases
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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