Publication Date:
1983-06-10
Description:
Treatment of spleen cells derived from adult thymectomized mice with thymosin fraction 5 resulted in a rapid and dose-dependent stimulation of the release of immunoreactive prostaglandin E2. The release of prostaglandin E2 was associated with induction of theta antigen and was totally inhibited by indomethacin. In contrast, prostaglandin E2 release from spleen cells from intact donors was inhibited by treatment with fraction 5. The data support the concept that prostaglandin E2 mediates the effects of thymosin fraction 5 on lymphocytes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rinaldi Garaci, C -- Favalli, C -- Del Gobbo, V -- Garaci, E -- Jaffe, B M -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1163-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6574601" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Dinoprostone
;
Dose-Response Relationship, Drug
;
Indomethacin/pharmacology
;
Lymphocytes/drug effects/physiology
;
Male
;
Mice
;
Mice, Inbred C57BL
;
Prostaglandins E/*physiology
;
Spleen/drug effects/physiology
;
Thymectomy
;
Thymosin/*pharmacology
;
Thymus Hormones/*pharmacology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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