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  • 1
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    Fast radiative cooling of anthracene: Dependence on internal energy (2015)
    American Physical Society (APS)
    Details
    Publication Date: 2015-11-26
    Description: Author(s): S. Martin, M. Ji, J. Bernard, R. Brédy, B. Concina, A. R. Allouche, C. Joblin, C. Ortega, G. Montagne, A. Cassimi, Y. Ngono-Ravache, and L. Chen Fast radiative cooling of anthracene cations ( C 14 H 10 ) + is studied with a compact electrostatic storage device, the Mini-Ring. The time evolution of the internal energy distribution of the stored ions is probed in a time range from 3 to 7 ms using laser-induced dissociation with 3.49-eV photons. The … [Phys. Rev. A 92, 053425] Published Wed Nov 25, 2015
    Keywords: Atomic and molecular processes in external fields, including interactions with strong fields and short pulses
    Print ISSN: 1050-2947
    Electronic ISSN: 1094-1622
    Topics: Physics
    Published by American Physical Society (APS)
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  • 2
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    Dual amyloid domains promote differential functioning of the chaplin proteins during Streptomyces aerial morphogenesis [Biochemistry] (2011)
    National Academy of Sciences
    Details
    Publication Date: 2011-06-15
    Description: The chaplin proteins are functional amyloids found in the filamentous Streptomyces bacteria. These secreted proteins are required for the aerial development of Streptomyces coelicolor, and contribute to an intricate rodlet ultrastructure that decorates the surfaces of aerial hyphae and spores. S. coelicolor encodes eight chaplin proteins. Previous studies have revealed that only three of these proteins (ChpC, ChpE, and ChpH) are necessary for promoting aerial development, and of these three, ChpH is the primary developmental determinant. Here, we show that the model chaplin, ChpH, contains two amyloidogenic domains: one in the N terminus and one in the C terminus of the mature protein. These domains have different polymerization properties as determined using fluorescence spectroscopy, secondary structure analyses, and electron microscopy. We coupled these in vitro assays with in vivo genetic studies to probe the connection between ChpH amyloidogenesis and its biological function. Using mutational analyses, we demonstrated that both N- and C-terminal amyloid domains of ChpH were required for promoting aerial hypha formation, while the N-terminal domain was dispensable for assembly of the rodlet ultrastructure. These results suggest that there is a functional differentiation of the dual amyloid domains in the chaplin proteins.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 3
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    Fast Radiative Cooling of Anthracene Observed in a Compact Electrostatic Storage Ring (2013)
    American Physical Society (APS)
    Details
    Publication Date: 2013-02-08
    Description: Author(s): S. Martin, J. Bernard, R. Brédy, B. Concina, C. Joblin, M. Ji, C. Ortega, and L. Chen Fast radiative cooling of anthracene was observed in a compact electrostatic storage ring by probing the evolution of the internal energy distribution of a stored (C 14 H 10 ) + molecular ensemble via laser excitation. We have measured the mean radiative decay rate to be about 120 to 250  s -1 for interna... [Phys. Rev. Lett. 110, 063003] Published Thu Feb 07, 2013
    Keywords: Atomic, Molecular, and Optical Physics
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
    Published by American Physical Society (APS)
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  • 4
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    Altered glycolipid and glycerophospholipid signaling drive inflammatory cascades in adrenomyeloneuropathy (2015)
    Oxford University Press
    Details
    Publication Date: 2015-11-21
    Description: X-linked adrenomyeloneuropathy (AMN) is an inherited neurometabolic disorder caused by malfunction of the ABCD1 gene, characterized by slowly progressing spastic paraplegia affecting corticospinal tracts, and adrenal insufficiency. AMN is the most common phenotypic manifestation of adrenoleukodystrophy (X-ALD). In some cases, an inflammatory cerebral demyelination occurs associated to poor prognosis in cerebral AMN (cAMN). Though ABCD1 codes for a peroxisomal transporter of very long-chain fatty acids, the molecular mechanisms that govern disease onset and progression, or its transformation to a cerebral, inflammatory demyelinating form, remain largely unknown. Here we used an integrated -omics approach to identify novel biomarkers and altered network dynamic characteristic of, and possibly driving, the disease. We combined an untargeted metabolome assay of plasma and peripheral blood mononuclear cells (PBMC) of AMN patients, which used liquid chromatography coupled to quadrupole-time-of-flight mass spectrometry (LC-Q-TOF), with a functional genomics analysis of spinal cords of Abcd1 – mouse. The results uncovered altered nodes in lipid-driven proinflammatory cascades, such as glycosphingolipid and glycerophospholipid synthesis, governed by the β-1,4-galactosyltransferase (B4GALT6), the phospholipase 2 (PLA2G4C) and the choline/ethanolamine phosphotransferase (CEPT1) enzymes. Confirmatory investigations revealed a non-classic, inflammatory profile, consisting on the one hand of raised plasma levels of several eicosanoids derived from arachidonic acid through PLA2G4C activity, together with also the proinflammatory cytokines IL6, IL8, MCP-1 and tumor necrosis factor-α. In contrast, we detected a more protective, Th2-shifted response in PBMC. Thus, our findings illustrate a previously unreported connection between ABCD1 dysfunction, glyco- and glycerolipid-driven inflammatory signaling and a fine-tuned inflammatory response underlying a disease considered non-inflammatory.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
    Published by Oxford University Press
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  • 5
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    Larval Diel Vertical Migration of the Marine Gastropod Kelletia kelletii (Forbes, 1850) (2012)
    Hindawi
    Details
    Publication Date: 2012-09-12
    Description: Documenting larval behavior is critical for building an understanding of larval dispersal dynamics and resultant population connectivity. Nocturnal diel vertical migration (DVM), a daily migration towards the surface of the water column at night and downward during the day, can profoundly influence dispersal outcomes. Via laboratory experiments we investigated whether marine gastropod Kelletia kelletii larvae undergo nocturnal DVM and whether the behavior was influenced by the presence of light, ontogeny, and laboratory culturing column height. Larvae exhibited a daily migration pattern consistent with nocturnal diel vertical migration with lower average vertical positioning (ZCM) during day-time hours and higher vertical positioning at night-time hours. ZCM patterns varied throughout ontogeny; larvae became more demersal as they approached competency. There was no effect of column height on larval ZCM. DVM behavior persisted in the absence of light, indicating a possible endogenous rhythm. Findings from field plankton tows corroborated laboratory nocturnal DVM findings; significantly more K. kelletii were found in surface waters at midnight compared to at noon. Unraveling the timing of and the cues initiating DVM behavior in K. kelletii larvae can help build predictive models of dispersal outcomes for this emerging fishery species.
    Print ISSN: 1687-9481
    Electronic ISSN: 1687-949X
    Topics: Biology
    Published by Hindawi
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  • 6
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    Electron capture and deprotonation processes observed in collisions between Xe8+ and multiply protonated cytochrome-C (2014)
    American Physical Society (APS)
    Details
    Publication Date: 2014-01-14
    Description: Author(s): S. Martin, C. Ortega, L. Chen, R. Brédy, A. Vernier, P. Dugourd, R. Antoine, J. Bernard, G. Reitsma, O. Gonzalez-Magaña, R. Hoekstra, and T. Schlathölter Electron-transfer processes in interaction between highly charged ions and multiply protonated proteins have been studied. Collisions between Xe8+ at 96 keV and protonated cytochrome-C at selected charge state (q from 15+ to 19+) result in mass spectra composed mainly of intact molecular ions. From ... [Phys. Rev. A 89, 012707] Published Mon Jan 13, 2014
    Keywords: Atomic and molecular collisions and interactions
    Print ISSN: 1050-2947
    Electronic ISSN: 1094-1622
    Topics: Physics
    Published by American Physical Society (APS)
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  • 7
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    Chemopreventive activity of systemically administered curcumin on oral cancer in the 4-nitroquinoline 1-oxide model (2014)
    Wiley
    Details
    Publication Date: 2014-12-17
    Description: Curcumin has therapeutic potential in preventing several types of cancer, including colon, liver, prostate and breast. The goal of this study was to evaluate the chemopreventive activity of systemically administered curcumin on oral carcinogenesis induced by 4-nitroquinolone-1-oxide (4-NQO). A total of 50 male albino rats, Rattus norvegicus , (Holtzman), were divided into five groups (n = 10 per group). Four of these groups were exposed to 50 ppm 4-NQO in their drinking water ad libitum for 8 or 12 weeks, two groups were treated with curcumin by oral gavage at 30 or 100 mg/kg per day, and one group was treated with corn oil (vehicle) only. The negative control group was euthanized at baseline. Tongues of all animals were removed after euthanasia and used in the subsequent analysis because the tongue is the primary site of carcinogenesis in this model. Descriptive histological analysis and immunohistochemistry for PCNA, Bcl-2, SOCS1 e-3, and STAT3 were performed to assess the oncogenic process. The gene expression of Vimentin, E-cadherin, N-cadherin, or TWIST1 was assessed using RT-qPCR as a representative of epithelial-mesenchymal transition (EMT) events. The administration of curcumin at 100 mg/kg during the 12 weeks markedly decreased the expression of PCNA, Bcl-2, SOCS1 e -3, and STAT3. Curcumin also minimized the cellular atypia under microscopic analysis and diminished the expression of the genes associated with EMT. These findings demonstrate that the systemic administration of curcumin has chemopreventive activity during oral carcinogenesis induced by 4-NQO. This article is protected by copyright. All rights reserved
    Electronic ISSN: 0091-7419
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Published by Wiley
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  • 8
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    The human malaria parasite Pfs47 gene mediates evasion of the mosquito immune system (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-05-11
    Description: Plasmodium falciparum transmission by Anopheles gambiae mosquitoes is remarkably efficient, resulting in a very high prevalence of human malaria infection in sub-Saharan Africa. A combination of genetic mapping, linkage group selection, and functional genomics was used to identify Pfs47 as a P. falciparum gene that allows the parasite to infect A. gambiae without activating the mosquito immune system. Disruption of Pfs47 greatly reduced parasite survival in the mosquito, and this phenotype could be reverted by genetic complementation of the parasite or by disruption of the mosquito complement-like system. Pfs47 suppresses midgut nitration responses that are critical to activate the complement-like system. We provide direct experimental evidence that immune evasion mediated by Pfs47 is critical for efficient human malaria transmission by A. gambiae.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807741/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807741/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Molina-Cruz, Alvaro -- Garver, Lindsey S -- Alabaster, Amy -- Bangiolo, Lois -- Haile, Ashley -- Winikor, Jared -- Ortega, Corrie -- van Schaijk, Ben C L -- Sauerwein, Robert W -- Taylor-Salmon, Emma -- Barillas-Mury, Carolina -- ZIA AI000947-09/Intramural NIH HHS/ -- New York, N.Y. -- Science. 2013 May 24;340(6135):984-7. doi: 10.1126/science.1235264. Epub 2013 May 9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23661646" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anopheles gambiae/*immunology/*parasitology ; Gene Knockout Techniques ; Humans ; Immune System ; Malaria, Falciparum/*parasitology/*transmission ; Membrane Glycoproteins/genetics/*physiology ; Plasmodium falciparum/genetics/*pathogenicity ; Protozoan Proteins/genetics/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    Statistical fragmentation of doubly charged anthracene induced by fluorine-beam impact at 3 keV (2012)
    American Physical Society (APS)
    Details
    Publication Date: 2012-05-30
    Description: Author(s): S. Martin, L. Chen, R. Brédy, G. Montagne, C. Ortega, T. Schlathölter, G. Reitsma, and J. Bernard The fragmentation scheme of the doubly charged anthracene molecule (C 14 H 10 2+ ) has been studied via monocharged fluorine impact at 3 keV using the CIDEC method (collision-induced dissociation under energy control). Doubly or singly charged fragments resulting from the loss of neutrals (H, C 2 H 2 ) or C x ... [Phys. Rev. A 85, 052715] Published Tue May 29, 2012
    Keywords: Atomic and molecular collisions and interactions
    Print ISSN: 1050-2947
    Electronic ISSN: 1094-1622
    Topics: Physics
    Published by American Physical Society (APS)
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  • 10
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    Larval Diel Vertical Migration of the Marine Gastropod Kelletia kelletii (Forbes, 1850) (2013)
    Hindawi
    Details
    Publication Date: 2013-01-22
    Description: Documenting larval behavior is critical for building an understanding of larval dispersal dynamics and resultant population connectivity. Nocturnal diel vertical migration (DVM), a daily migration towards the surface of the water column at night and downward during the day, can profoundly influence dispersal outcomes. Via laboratory experiments we investigated whether marine gastropod Kelletia kelletii larvae undergo nocturnal DVM and whether the behavior was influenced by the presence of light, ontogeny, and laboratory culturing column height. Larvae exhibited a daily migration pattern consistent with nocturnal diel vertical migration with lower average vertical positioning (ZCM) during day-time hours and higher vertical positioning at night-time hours. ZCM patterns varied throughout ontogeny; larvae became more demersal as they approached competency. There was no effect of column height on larval ZCM. DVM behavior persisted in the absence of light, indicating a possible endogenous rhythm. Findings from field plankton tows corroborated laboratory nocturnal DVM findings; significantly more K. kelletii were found in surface waters at midnight compared to at noon. Unraveling the timing of and the cues initiating DVM behavior in K. kelletii larvae can help build predictive models of dispersal outcomes for this emerging fishery species.
    Print ISSN: 1687-9481
    Electronic ISSN: 1687-949X
    Topics: Biology
    Published by Hindawi
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