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  • 1
    Publication Date: 2013-12-11
    Description: An autochthonous model of pancreatic ductal adenocarcinoma (PDA) permitted the analysis of why immunotherapy is ineffective in this human disease. Despite finding that PDA-bearing mice had cancer cell-specific CD8+ T cells, the mice, like human patients with PDA, did not respond to two immunological checkpoint antagonists that promote the function...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 2
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2003-10-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chivian, Eric -- Roberts, Callum M -- Bernstein, Aaron S -- New York, N.Y. -- Science. 2003 Oct 17;302(5644):391.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14563988" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anthozoa ; Biomedical Research ; Conotoxins ; *Conservation of Natural Resources ; *Ecosystem ; Environment ; *Snails
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 2001-12-01
    Description: Marine reserves have been widely promoted as conservation and fishery management tools. There are robust demonstrations of conservation benefits, but fishery benefits remain controversial. We show that marine reserves in Florida (United States) and St. Lucia have enhanced adjacent fisheries. Within 5 years of creation, a network of five small reserves in St. Lucia increased adjacent catches of artisanal fishers by between 46 and 90%, depending on the type of gear the fishers used. In Florida, reserve zones in the Merritt Island National Wildlife Refuge have supplied increasing numbers of world record-sized fish to adjacent recreational fisheries since the 1970s. Our study confirms theoretical predictions that marine reserves can play a key role in supporting fisheries.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roberts, C M -- Bohnsack, J A -- Gell, F -- Hawkins, J P -- Goodridge, R -- New York, N.Y. -- Science. 2001 Nov 30;294(5548):1920-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA. cr10@york.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11729316" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Aged ; Aged, 80 and over ; Animals ; Biomass ; Cnidaria/physiology ; Conservation of Natural Resources/*methods ; *Ecosystem ; Fisheries/*methods/statistics & numerical data ; *Fishes/physiology ; Florida ; Humans ; Middle Aged ; Saint Lucia ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1997-11-21
    Description: Surface current patterns were used to map dispersal routes of pelagic larvae from 18 coral reef sites in the Caribbean. The sites varied, both as sources and recipients of larvae, by an order of magnitude. It is likely that sites supplied copiously from "upstream" reef areas will be more resilient to recruitment overfishing, less susceptible to species loss, and less reliant on local management than places with little upstream reef. The mapping of connectivity patterns will enable the identification of beneficial management partnerships among nations and the design of networks of interdependent reserves.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roberts -- New York, N.Y. -- Science. 1997 Nov 21;278(5342):1454-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Environment Department, University of York, York YO1 5DD, UK. E-mail: cr10@york.ac.uk.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9367956" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
    Publication Date: 2002-02-16
    Description: Coral reefs are the most biologically diverse of shallow water marine ecosystems but are being degraded worldwide by human activities and climate warming. Analyses of the geographic ranges of 3235 species of reef fish, corals, snails, and lobsters revealed that between 7.2% and 53.6% of each taxon have highly restricted ranges, rendering them vulnerable to extinction. Restricted-range species are clustered into centers of endemism, like those described for terrestrial taxa. The 10 richest centers of endemism cover 15.8% of the world's coral reefs (0.012% of the oceans) but include between 44.8 and 54.2% of the restricted-range species. Many occur in regions where reefs are being severely affected by people, potentially leading to numerous extinctions. Threatened centers of endemism are major biodiversity hotspots, and conservation efforts targeted toward them could help avert the loss of tropical reef biodiversity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roberts, Callum M -- McClean, Colin J -- Veron, John E N -- Hawkins, Julie P -- Allen, Gerald R -- McAllister, Don E -- Mittermeier, Cristina G -- Schueler, Frederick W -- Spalding, Mark -- Wells, Fred -- Vynne, Carly -- Werner, Timothy B -- New York, N.Y. -- Science. 2002 Feb 15;295(5558):1280-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Organismic and Evolutionary Biology, Harvard University, Cambridge MA 02138, USA. cr10@york.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11847338" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cnidaria/classification/physiology ; *Conservation of Natural Resources ; *Ecosystem ; *Fishes/classification/physiology ; Humans ; *Nephropidae/classification/physiology ; Seawater ; *Snails/classification/physiology ; Tropical Climate
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
    Publication Date: 2012-06-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Veitch, Liane -- Dulvy, Nicholas K -- Koldewey, Heather -- Lieberman, Susan -- Pauly, Daniel -- Roberts, Callum M -- Rogers, Alex D -- Baillie, Jonathan E M -- New York, N.Y. -- Science. 2012 Jun 15;336(6087):1383-5. doi: 10.1126/science.1223009.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Zoological Society of London, London NW1 4RY, UK. liane.veitch@zsl.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22700905" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Aquatic Organisms ; Biodiversity ; *Conservation of Natural Resources ; *Ecosystem ; *Fisheries ; Fishes ; *International Cooperation ; Oceans and Seas ; Public Policy ; *Seawater ; United Nations
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
    Publication Date: 2014-05-31
    Description: Recent studies clarify where the most vulnerable species live, where and how humanity changes the planet, and how this drives extinctions. We assess key statistics about species, their distribution, and their status. Most are undescribed. Those we know best have large geographical ranges and are often common within them. Most known species have small ranges. The numbers of small-ranged species are increasing quickly, even in well-known taxa. They are geographically concentrated and are disproportionately likely to be threatened or already extinct. Current rates of extinction are about 1000 times the likely background rate of extinction. Future rates depend on many factors and are poised to increase. Although there has been rapid progress in developing protected areas, such efforts are not ecologically representative, nor do they optimally protect biodiversity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pimm, S L -- Jenkins, C N -- Abell, R -- Brooks, T M -- Gittleman, J L -- Joppa, L N -- Raven, P H -- Roberts, C M -- Sexton, J O -- New York, N.Y. -- Science. 2014 May 30;344(6187):1246752. doi: 10.1126/science.1246752.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Nicholas School of the Environment, Duke University, Box 90328, Durham, NC 27708, USA. stuartpimm@me.com. ; Instituto de Pesquisas Ecologicas, Rodovia Dom Pedro I, km 47, Caixa Postal 47, Nazare Paulista SP, 12960-000, Brazil. ; Post Office Box 402 Haverford, PA 19041, USA. ; International Union for Conservation of Nature, IUCN, 28 Rue Mauverney, CH-1196 Gland, Switzerland. ; Odum School of Ecology, University of Georgia, Athens, GA 30602, USA. ; Microsoft Research, 21 Station Road, Cambridge, CB1 2FB, UK. ; Missouri Botanical Garden, Post Office Box 299, St. Louis, MO 63166-0299, USA. ; Environment Department, University of York, York, YO10 5DD, UK. ; Global Land Cover Facility, Department of Geographical Sciences, University of Maryland, College Park, MD, 20742, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24876501" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biodiversity ; Conservation of Natural Resources/*methods ; *Endangered Species ; *Extinction, Biological ; Geography ; Humans ; Population Dynamics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Marine geophysical researches 12 (1990), S. 49-57 
    ISSN: 1573-0581
    Keywords: seismic refraction ; lithosphere ; continental shelf
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract Previous experiments to record seismic data at wide angle on the continental shelf have generally been unsuccessful in determining velocity structure in the lower crust; either the lines were too short or shot-receiver density too sparse to identify lower crustal arrivals. In contrast, deep normal incidence profiles show good structural resolution in the crust and uppermost mantle. A sea-bottom multichannel instrument has been developed to record datasets containing closely spaced traces, in order to improve the resolution of reversed wide-angle experiments on the continental shelf. The Pull-up Multichannel Array (PUMA) is a 1200 m, 12-channel hydrophone array for remotely recording seismic data on the seabed. It consists of 12 short hydrophone sections linked by 100 m-long passive sections. A pressure case is attached to the array at one end, in which recording electronics, cassette tape recorders and a battery power supply are housed. The PUMA is designed for deployment in water depths less than 200 m from a research ship and is moored to buoys for recovery. The instrument, which was successfully used in an experiment west of Lewis, Outer Hebrides, UK (Powell and Sinha, 1987) was specifically designed to provide a reliable determination of the velocity structure of the crust and uppermost mantle over part of the BIRPS WINCH deep normal incidence profile. Because the traces are closely spaced it is easy to correlate phases across the record section and to monitor changes in amplitude. A velocity structure for the continental crust and uppermost mantle has been devised from these data, using amplitude modelling.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Coral reefs 13 (1994), S. 90-90 
    ISSN: 1432-0975
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geosciences
    Type of Medium: Electronic Resource
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  • 10
    Publication Date: 2004-06-17
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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