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  • 1
    Monograph available for loan
    Monograph available for loan
    Study of air pollutant detection by remote sensors (1969)
    Washington, DC : National Aeronautics and Space Administration
    Associated volumes
    Details Availability
    Call number: MOP 43243 / Mitte ; MOP B 14977
    In: NASA contractor report
    Type of Medium: Monograph available for loan
    Pages: Getr. Zählung. : graph. Darst.
    Series Statement: NASA contractor report CR-1380
    Location: MOP - must be ordered
    Location: MOP - must be ordered
    Branch Library: GFZ Library
    Branch Library: GFZ Library
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  • 2
    Monograph available for loan
    Monograph available for loan
    Atmospheric effects on radiative transfer : Aug. 29-30, 1979 San Diego, Calif. (1979)
    Bellingham, Wash. : Soc. of Photo-Optical Instrumentation Engineers
    Details Availability
    Call number: MOP 45271 / Mitte
    Type of Medium: Monograph available for loan
    Pages: VIII, 236 S.
    ISBN: 0892522232
    Series Statement: Proceedings of the Society of Photo-Optical Instrumentation Engineers 195
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    Branch Library: GFZ Library
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  • 3
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    The human H3N2 influenza viruses A/Victoria/3/75 and A/Hiroshima/52/2005 preferentially bind to {alpha}2-3-sialylated monosialogangliosides with fucosylated poly-N-acetyllactosaminyl chains (2012)
    Oxford University Press
    Details
    Publication Date: 2012-06-26
    Description: Among influenza A viruses, subtype H3N2 is the major cause of human influenza morbidity and is associated with seasonal epidemics causing annually half million deaths worldwide. Influenza A virus infection is initiated via hemagglutinin that binds to terminally sialylated glycoconjugates exposed on the surface of target cells. Gangliosides from human granulocytes were probed using thin-layer chromatography overlay assays for their binding potential to H3N2 virus strains A/Victoria/3/75 and A/Hiroshima/52/2005. Highly polar gangliosides with poly- N -acetyllactosaminyl chains showing low chromatographic mobility exhibited strong virus adhesion which was entirely abolished by sialidase treatment. Auxiliary overlay assays using anti-sialyl Lewis x (sLe x ) monoclonal antibodies showed identical binding patterns compared with those performed with the viruses. A comprehensive structural analysis of fractionated gangliosides by electrospray ionization quadrupole time-of-flight mass spectrometry revealed sLe x gangliosides with terminal Neu5Acα2-3Galβ1-4(Fucα1-3)GlcNAc epitope and extended neolacto (nLc)-series core structures as the preferential virus binding gangliosides. More precisely, sLe x gangliosides with nLc8, nLc10 and nLc12Cer cores, carrying sphingosine (d18:1) and a fatty acid with variable chain length (mostly C24:0, C24:1 or C16:0) in the ceramide moiety and one or two additional internal fucose residues in the oligosaccharide portion, were identified as the preferred receptors recognized by H3N2 virus strains A/Victoria/3/75 and A/Hiroshima/52/2005. This study describes glycan-binding requirements of hemagglutinin beyond binding to glycans with a specific sialic acid linkage of as yet undefined neutrophil receptors acting as ligands for H3N2 viruses. In addition, our results pose new questions on the biological and clinical relevance of this unexpected specificity of a subtype of influenza A viruses.
    Print ISSN: 0959-6658
    Electronic ISSN: 1460-2423
    Topics: Biology , Medicine
    Published by Oxford University Press
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  • 4
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    Tregs use PD-L to directly suppress B cells [Immunology] (2012)
    National Academy of Sciences
    Details
    Publication Date: 2012-06-27
    Description: The mechanisms by which regulatory T cells (Tregs) suppress autoantibody production are unclear. Here we have addressed this question using transgenic mice expressing model antigens in the kidney. We report that Tregs were essential and sufficient to suppress autoreactive B cells in an antigen-specific manner and to prevent them from producing autoantibodies. Most of this suppression was mediated through the inhibitory cell-surface-molecule programmed death-1 (PD-1). Suppression required PD-1 expression on autoreactive B cells and expression of the two PD-1 ligands on Tregs. PD-1 ligation inhibited activation of autoreactive B cells, suppressed their proliferation, and induced their apoptosis. Intermediate PD-1+ cells, such as T helper cells, were dispensable for suppression. These findings demonstrate in vivo that Tregs use PD-1 ligands to directly suppress autoreactive B cells, and they identify a previously undescribed peripheral B-cell tolerance mechanism against tissue autoantigens.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 5
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    Characterization of Silver Nanoparticle Products Using Asymmetric Flow Field Flow Fractionation with a Multidetector Approach – a Comparison to Transmission Electron Microscopy and Batch Dynamic Light Scattering (2012)
    American Chemical Society (ACS)
    Details
    Publication Date: 2012-03-01
    Description: Analytical Chemistry DOI: 10.1021/ac202641d
    Print ISSN: 0003-2700
    Electronic ISSN: 1520-6882
    Topics: Chemistry and Pharmacology
    Published by American Chemical Society (ACS)
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  • 6
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    Anatectic Granitic Pegmatites from the Eastern Alps: A Case of Variable Rare Metal Enrichment During High-Grade Regional Metamorphism. II: Pegmatite Staurolite As an Indicator of Anatectic Pegmatite Parent Melt Formation – A Field and Experimental Study (2018)
    Mineralogical Association of Canada
    Details
    Publication Date: 2018
    Description: 〈span〉〈div〉Abstract〈/div〉Staurolite was found in two granitic pegmatites emplaced in crystalline basement rocks of the Eastern Alps in Northern Italy. The pegmatites form decimeter- to meter-sized concordant veins with quartz + albite + muscovite + paragonite as major phases along with minor garnet + beryl and accessory Nb-Ta-Sn-Ti phases, zircon, and magmatic phosphate minerals. U-Pb dating of cassiterite from one of the pegmatites yielded Permian ages of ∼290 Ma. The pegmatite country rocks are garnet-biotite-muscovite-plagioclase gneisses with accessory paragonite ± staurolite ± kyanite. The pegmatite staurolites are present as an accessory groundmass phase with sizes typically ≤∼200–300 μm and as tiny (∼10–50 μm) inclusions in large beryl crystals. When enclosed in beryl staurolite is typically intergrown with quartz and is part of a complex solid phase assemblage including tapiolite, chrysoberyl, cordierite, and Zn-Al-spinel. With few exceptions, the staurolites from the pegmatites are perfectly euhedral and free of solid inclusions. They are Fe-rich with 〈span〉X〈/span〉〈sub〉Mg〈/sub〉 = 0.02–0.20 and contain 0.6–7.2 wt.% ZnO, 〈0.05–0.4 wt.% TiO〈sub〉2〈/sub〉, 0.48–0.69 wt.% Li〈sub〉2〈/sub〉O, and ∼1.8 wt.% H〈sub〉2〈/sub〉O. With respect to trace elements, high Be (96–171 μg/g), Nb (18–49 μg/g), and Ta (10–72 μg/g) contents are noteworthy, as is a very low Nb/Ta ratio of 0.6–1.9. Staurolites from the pegmatite country rock show a comparable range in 〈span〉X〈/span〉〈sub〉Mg〈/sub〉 of 0.16–0.23 and an identical H〈sub〉2〈/sub〉O content but are significantly different in TiO〈sub〉2〈/sub〉 (0.49–0.92 wt.%), ZnO (0.1–2.4 wt.%), and Li〈sub〉2〈/sub〉O (0.06–0.31 wt.%) contents. Also, Be (13–48 μg/g), Nb (0.4–4.7 μg/g), and Ta (0.04–1.2 μg/g) contents are much lower and Nb/Ta ratios of 4.0–10.9 are higher than in the pegmatite staurolites. In both pegmatites and country rocks staurolite is the major Li carrier and one of the major Ta-fractionating silicate phases. The unusual paragenetic and textural features of the pegmatite staurolites suggest that they are magmatic rather than metamorphic in origin. Partial-melting experiments at 7 kbar and 650–750 °C confirm the potential of the pegmatite country rocks to generate strongly peraluminous granitic melts in equilibrium with staurolite and may produce staurolite textures very similar to those found in the pegmatites. Hence, both field and experimental data are consistent with magmatic formation of the pegmatite staurolites and an origin of the pegmatite parent melts by anatexis of metapelites during the Permian high-〈span〉T〈/span〉/low-〈span〉P〈/span〉 tectonometamorphic event, which affected significant portions of the Eastern Alpine crystalline basement.〈/span〉
    Print ISSN: 0008-4476
    Electronic ISSN: 1499-1276
    Topics: Geosciences
    Published by Mineralogical Association of Canada
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  • 7
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    Multi-omics enrichment analysis using the GeneTrail2 web service (2016)
    Oxford University Press
    Details
    Publication Date: 2016-05-14
    Description: Motivation : Gene set analysis has revolutionized the interpretation of high-throughput transcriptomic data. Nowadays, with comprehensive studies that measure multiple -omics from the same sample, powerful tools for the integrative analysis of multi-omics datasets are required. Results : Here, we present GeneTrail2, a web service allowing the integrated analysis of transcriptomic, miRNomic, genomic and proteomic datasets. It offers multiple statistical tests, a large number of predefined reference sets, as well as a comprehensive collection of biological categories and enables direct comparisons between the computed results. We used GeneTrail2 to explore pathogenic mechanisms of Wilms tumors. We not only succeeded in revealing signaling cascades that may contribute to the malignancy of blastemal subtype tumors but also identified potential biomarkers for nephroblastoma with adverse prognosis. The presented use-case demonstrates that GeneTrail2 is well equipped for the integrative analysis of comprehensive -omics data and may help to shed light on complex pathogenic mechanisms in cancer and other diseases. Availability and implementation : GeneTrail2 can be freely accessed under https://genetrail2.bioinf.uni-sb.de . Contact : dstoeckel@bioinf.uni-sb.de Supplementary information: Supplementary data are available at Bioinformatics online.
    Print ISSN: 1367-4803
    Electronic ISSN: 1460-2059
    Topics: Biology , Computer Science , Medicine
    Published by Oxford University Press
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  • 8
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    Genome editing of GATA1-bound cis elements [Genetics] (2016)
    National Academy of Sciences
    Details
    Publication Date: 2016-04-20
    Description: Whole-exome sequencing has been incredibly successful in identifying causal genetic variants and has revealed a number of novel genes associated with blood and other diseases. One limitation of this approach is that it overlooks mutations in noncoding regulatory elements. Furthermore, the mechanisms by which mutations in transcriptional cis-regulatory elements result...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 9
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    Cell competition is a tumour suppressor mechanism in the thymus (2014)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2014-05-16
    Description: Cell competition is an emerging principle underlying selection for cellular fitness during development and disease. Competition may be relevant for cancer, but an experimental link between defects in competition and tumorigenesis is elusive. In the thymus, T lymphocytes develop from precursors that are constantly replaced by bone-marrow-derived progenitors. Here we show that in mice this turnover is regulated by natural cell competition between 'young' bone-marrow-derived and 'old' thymus-resident progenitors that, although genetically identical, execute differential gene expression programs. Disruption of cell competition leads to progenitor self-renewal, upregulation of Hmga1, transformation, and T-cell acute lymphoblastic leukaemia (T-ALL) resembling the human disease in pathology, genomic lesions, leukaemia-associated transcripts, and activating mutations in Notch1. Hence, cell competition is a tumour suppressor mechanism in the thymus. Failure to select fit progenitors through cell competition may explain leukaemia in X-linked severe combined immune deficiency patients who showed thymus-autonomous T-cell development after therapy with gene-corrected autologous progenitors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Martins, Vera C -- Busch, Katrin -- Juraeva, Dilafruz -- Blum, Carmen -- Ludwig, Carolin -- Rasche, Volker -- Lasitschka, Felix -- Mastitsky, Sergey E -- Brors, Benedikt -- Hielscher, Thomas -- Fehling, Hans Joerg -- Rodewald, Hans-Reimer -- England -- Nature. 2014 May 22;509(7501):465-70. doi: 10.1038/nature13317. Epub 2014 May 14.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] Division of Cellular Immunology, German Cancer Research Center, D-69120 Heidelberg, Germany [2] Institute of Immunology, University of Ulm, D-89081 Ulm, Germany. ; Division of Cellular Immunology, German Cancer Research Center, D-69120 Heidelberg, Germany. ; Division of Theoretical Bioinformatics, German Cancer Research Center, D-69120 Heidelberg, Germany. ; Institute of Immunology, University of Ulm, D-89081 Ulm, Germany. ; Core Facility Small Animal MRI, University of Ulm, D-89081 Ulm, Germany. ; Institute of Pathology, University Hospital Heidelberg, Im Neuenheimer Feld 224, 69120 Heidelberg, Germany. ; Division of Biostatistics, German Cancer Research Center, D-69120 Heidelberg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24828041" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Division ; Cell Movement ; *Cell Transformation, Neoplastic/genetics ; Disease Progression ; Female ; Gene Expression Regulation, Neoplastic ; HMGA Proteins/genetics ; Hematopoietic Stem Cells/*cytology/metabolism ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/genetics/*pathology ; Receptor, Notch1/genetics ; T-Lymphocytes/cytology/metabolism/pathology ; Thymus Gland/*cytology/pathology ; Transcriptome/genetics
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 10
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    TIGAR stimulates HK2 [Cell Biology] (2012)
    National Academy of Sciences
    Details
    Publication Date: 2012-12-12
    Description: The p53-inducible protein TIGAR (Tp53-induced Glycolysis and Apoptosis Regulator) functions as a fructose-2,6-bisphosphatase (Fru-2,6-BPase), and through promotion of the pentose phosphate pathway, increases NADPH production to help limit reactive oxygen species (ROS). Here, we show that under hypoxia, a fraction of TIGAR protein relocalized to mitochondria and formed a complex...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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