Publication Date:
1990-09-21
Description:
During the development of a vertebrate embryo, cell fate is determined by inductive signals passing between neighboring tissues. Such determinative interactions have been difficult to characterize fully without knowledge of the molecular mechanisms involved. Mutations of Drosophila and the nematode Caenorhabditis elegans have been isolated that define a family of related gene products involved in similar types of cellular inductions. One of these genes, the Notch gene from Drosophila, is involved with cell fate choices in the neurogenic region of the blastoderm, in the developing nervous system, and in the eye-antennal imaginal disc. Complementary DNA clones were isolated from Xenopus embryos with Notch DNA in order to investigate whether cell-cell interactions in vertebrate embryos also depend on Notch-like molecules. This approach identified a Xenopus molecule, Xotch, which is remarkably similar to Drosophila Notch in both structure and developmental expression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Coffman, C -- Harris, W -- Kintner, C -- New York, N.Y. -- Science. 1990 Sep 21;249(4975):1438-41.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, University of California, La Jolla 92093.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2402639" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
Drosophila/*genetics
;
Embryo, Nonmammalian/physiology
;
*Genes
;
Molecular Sequence Data
;
Nervous System/embryology
;
Sequence Homology, Nucleic Acid
;
Xenopus/*genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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