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  • 1
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    Growth-promoting effects of glycine-extended progastrin (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-07-15
    Description: Peptide alpha amidation is required to produce some hormones, such as gastrin, from their glycine-extended precursors. This terminal posttranslational processing reaction is thought to be essential for the biological activation of many peptide hormones; only amidated gastrin exerts a physiological effect that results in gastric acid secretion. However, both amidated gastrin and glycine-extended gastrin stimulate proliferation of exocrine pancreatic cell line AR4-2J through selective receptors for the substrate and the product, respectively, of peptide alpha amidation. Thus, the amidation reaction may function as a determinant of the specific biological actions of products derived from prohormones.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Seva, C -- Dickinson, C J -- Yamada, T -- K08-DK-01903/DK/NIDDK NIH HHS/ -- P30-DK-34933/DK/NIDDK NIH HHS/ -- R01-DK-34306/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 1994 Jul 15;265(5170):410-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8023165" target="_blank"〉PubMed〈/a〉
    Keywords: Benzodiazepinones/pharmacology ; Binding Sites ; Cell Division/*drug effects ; Gastrins/metabolism/*pharmacology ; Humans ; Indoles/pharmacology ; Meglumine/analogs & derivatives/pharmacology ; Octreotide/pharmacology ; Ornithine Decarboxylase/metabolism ; *Phenylurea Compounds ; Receptors, Cholecystokinin/antagonists & inhibitors ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
    Electronic Resource
    Electronic Resource
    Rapid Contractile Properties of Isolated Mammalian Arteries (1960)
    [s.l.] : Nature Publishing Group
    Nature 185 (1960), S. 620-621 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Paton's technique3 has been used to study the behaviour of 2-3 cm. lengths of dog's common carotid, femoral, hepatic and splenic arteries, and of sheep's hepatic and splenic arteries. The excised artery was tied on a glass cannula which formed a closed system connected to a manometer (Hansen ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/185620a0
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    A digital computer model of the effects of gravitational stress upon the heart and venous system (1969)
    Springer
    Medical & biological engineering & computing 7 (1969), S. 267-275 
    Details
    ISSN: 1741-0444
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Description / Table of Contents: Sommaire Un modèle digital a été élaboré pour l'étude des effets que provoque sur le coeur et le système veineux le basculement de la tête de haut en bas; ce modèle présente dans l'un et l'autre cas des propriétés fonctionnelles suffisamment réalistes. Le système veineux est considéré comme une série de segments de longueurs égales dont l'un est identifié à l'oreillette droite. Les capacitances de chacun de ces segments peuvent être ajustées individuellement de façon à permettre une étude réelle de la distribution du sang. Le programme calcule les volume, pression et débit escomptés dans chacun des segments, dans différentes conditions de choc. Cela permet de prévoir le point du système où la pression change le moins en fonction des chocs.
    Abstract: Zusammenfassung Zum Studium der Wirkung von Auf- und Abkippen des Kopfes auf das Herz und Venensystem wurde ein Digitalrechnermodell entwickelt, welches verhältnismäßig realistische funktionelle Eigenschaften ergibt. Das Venensystem wird als eine Reihe von gleichlangen Segmenten aufgefaßt; eines wird als der rechte Vorhof angesetzt. Die Segmentkapazitanz kann individuell justiert werden, um realistische Blutverteilungen untersuchen zu können. Das Programm berechnet die erwarteten Volumina, Drucke und Durchflüsse in jedem Segment bei verschiedenen Kippungsbedingungen. Damit kann der Punkt in dem System berechnet werden, an dem sich der Druck mit der Körperkippung am geringsten ändert.
    Notes: Abstract A digital computer model has been made to study the effects of head up and head down tilt upon the heart and venous system, giving to both reasonably realistic functional properties. The venous system is treated as a series of segments of equal length, one of which is taken to be the right atrium. Provision is made for segmental capacitances to be individually adjusted, to allow realistic blood distributions to be studied. The programme calculates expected volumes, pressures and flows in each segment under different conditions of tilt, thus allowing prediction of the point in the system at which pressure changes least with body tilting.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02474766
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  • 4
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    ALMA observations of 99 GHz free-free and H40{alpha} line emission from star formation in the centre of NGC 253 (2015)
    Oxford University Press
    Details
    Publication Date: 2015-05-03
    Description: We present Atacama Large Millimeter/submillimeter Array observations of 99.02 GHz free–free and H40α emission from the centre of the nearby starburst galaxy NGC 253. We calculate electron temperatures of 3700–4500 K for the photoionized gas, which agrees with previous measurements. We measure a photoionizing photon production rate of (3.2 ± 0.2) 10 53  s –1 and a star formation rate of 1.73 ± 0.12 M  yr –1 within the central 20 10 arcsec, which fall within the broad range of measurements from previous millimetre and radio observations but which are better constrained. We also demonstrate that the dust opacities are ~3 dex higher than inferred from previous near-infrared data, which illustrates the benefits of using millimetre star formation tracers in very dusty sources.
    Print ISSN: 1745-3925
    Electronic ISSN: 1745-3933
    Topics: Physics
    Published by Oxford University Press
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  • 5
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    The pros and cons of the inversion method approach to derive 3D dust emission properties in the ISM: the Hi-GAL field centred on (l, b) = (30{degrees}, 0{degrees}) (2014)
    Oxford University Press
    Details
    Publication Date: 2014-04-20
    Description: Herschel far-infrared continuum data obtained as part of the Hi-GAL survey have been used, together with the GLIMPSE 8 μm and MIPSGAL 24 μm data, to attempt the first 3D-decomposition of dust emission associated with atomic, molecular and ionized gas at 15 arcmin angular resolution. Our initial test case is a 2 2 square degrees region centred on ( l , b ) = (30°, 0°), a direction that encompasses the origin point of the Scutum–Crux Arm at the tip of the Galactic Bar. Coupling the IR maps with velocity maps specific for different gas phases (H i 21cm, 12 CO and 13 CO, and radio recombination lines), we estimate the properties of dust blended with each of the gas components and at different Galactocentric distances along the line of sight (LOS). A statistical Pearson's coefficients analysis is used to study the correlation between the column densities estimated for each gas component and the intensity of the IR emission. This analysis provides evidence that the 2 2 square degree field under consideration is characterized by the presence of a gas component not accounted for by the standard tracers, possibly associated with warm H 2 and cold H i . We demonstrate that the IR radiation in the range 8 〈  〈 500 μm is systematically dominated by emission originating within the Scutum–Crux Arm. By applying an inversion method, we recover the dust emissivities associated with atomic, molecular and ionized gas. Using the DustEM model, we fit the spectral energy distributions for each gas phase, and find average dust temperatures of T d,H i  = 18.82 ± 0.47 K, T d,H 2  = 18.84 ± 1.06 K and T d,H ii  = 22.56 ± 0.64 K, respectively. We also obtain an indication for polycyclic aromatic hydrocarbons depletion in the diffuse ionized gas. We demonstrate the importance of including the ionized component in 3D-decompositions of the total IR emission. However, the main goal of this work is to discuss the impact of the missing column density associated with the dark gas component on the accurate evaluation of the dust properties, and to shed light on the limitations of the inversion method approach when this is applied to a small section of the Galactic plane and when the working resolution allows sufficient de-blending of the gas components along the LOS.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press
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  • 6
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    Free-free and H42{alpha} emission from the dusty starburst within NGC 4945 as observed by ALMA (2016)
    Oxford University Press
    Details
    Publication Date: 2016-09-10
    Description: We present observations of the 85.69 GHz continuum emission and H42α line emission from the central 30 arcsec within NGC 4945. Both sources of emission originate from nearly identical structures that can be modelled as exponential discs with scalelengths of ~2.1 arcsec (or ~40 pc). An analysis of the spectral energy distribution based on combining these data with archival data imply that 84 ± 10 per cent of the 85.69 GHz continuum emission originates from free–free emission. The electron temperature is 5400 ± 600 K, which is comparable to what has been measured near the centre of the Milky Way Galaxy. The star formation rate (SFR) based on the H42α and 85.69 GHz free–free emission (and using a distance of 3.8 Mpc) is 4.35 ± 0.25 M  yr –1 . This is consistent with the SFR from the total infrared flux and with previous measurements based on recombination line emission, and it is within a factor of ~2 of SFRs derived from radio data. The Spitzer Space Telescope 24 μm data and Wide-field Infrared Survey Explorer 22 μm data yield SFRs ~10 x lower than the Atacama Large Millimeter/submillimeter Array measurements, most likely because the mid-infrared data are strongly affected by dust attenuation equivalent to A V = 150. These results indicate that SFRs based on mid-infrared emission may be highly inaccurate for dusty, compact circumnuclear starbursts.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press
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  • 7
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    The C-Band All-Sky Survey (C-BASS): design and implementation of the northern receiver (2014)
    Oxford University Press
    Details
    Publication Date: 2014-02-15
    Description: The C-Band All-Sky Survey is a project to map the full sky in total intensity and linear polarization at 5 GHz. The northern component of the survey uses a broad-band single-frequency analogue receiver fitted to a 6.1-m telescope at the Owens Valley Radio Observatory in California, USA. The receiver architecture combines a continuous-comparison radiometer and a correlation polarimeter in a single receiver for stable simultaneous measurement of both total intensity and linear polarization, using custom-designed analogue receiver components. The continuous-comparison radiometer measures the temperature difference between the sky and temperature-stabilized cold electrical reference loads. A cryogenic front-end is used to minimize receiver noise, with a system temperature of 30 K in both linear polarization and total intensity. Custom cryogenic notch filters are used to counteract man-made radio frequency interference. The radiometer 1/ f noise is dominated by atmospheric fluctuations, while the polarimeter achieves a 1/ f noise knee frequency of 10 mHz, similar to the telescope azimuthal scan frequency.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press
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  • 8
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    Rapid Contractile Properties of Isolated Mammalian Arteries (1960)
    Springer Nature
    Details
    Publication Date: 1960-02-01
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Springer Nature
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  • 9
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    Review: Book review (1975)
    Oxford University Press
    Details
    Publication Date: 1975-01-01
    Print ISSN: 0010-4620
    Electronic ISSN: 1460-2067
    Topics: Computer Science
    Published by Oxford University Press
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  • 10
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    Interstellar chemistry and the tight far-infrared-radio correlation (1993)
    Oxford University Press
    Details
    Publication Date: 1993-07-01
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press on behalf of The Royal Astronomical Society.
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