Publication Date:
2008-03-01
Description:
The specification and maintenance of growth sites are tightly regulated during cell morphogenesis in all organisms. ROOT HAIR DEFECTIVE 2 reduced nicotinamide adenine dinucleotide phosphate (RHD2 NADPH) oxidase-derived reactive oxygen species (ROS) stimulate a Ca2+ influx into the cytoplasm that is required for root hair growth in Arabidopsis thaliana. We found that Ca2+, in turn, activated the RHD2 NADPH oxidase to produce ROS at the growing point in the root hair. Together, these components could establish a means of positive feedback regulation that maintains an active growth site in expanding root hair cells. Because the location and stability of growth sites predict the ultimate form of a plant cell, our findings demonstrate how a positive feedback mechanism involving RHD2, ROS, and Ca2+ can determine cell shape.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Takeda, Seiji -- Gapper, Catherine -- Kaya, Hidetaka -- Bell, Elizabeth -- Kuchitsu, Kazuyuki -- Dolan, Liam -- BBS/B/04498/Biotechnology and Biological Sciences Research Council/United Kingdom -- New York, N.Y. -- Science. 2008 Feb 29;319(5867):1241-4. doi: 10.1126/science.1152505.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell and Developmental Biology, John Innes Centre, Norwich NR4 7UH, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18309082" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Substitution
;
Arabidopsis/cytology/growth & development/*metabolism
;
Arabidopsis Proteins/chemistry/genetics/*metabolism
;
Calcium/*metabolism
;
Cation Transport Proteins/metabolism
;
Cell Line
;
Cell Shape
;
EF Hand Motifs
;
Endocytosis
;
*Feedback, Physiological
;
Humans
;
Mutant Proteins/chemistry/metabolism
;
NADPH Oxidase/chemistry/genetics/*metabolism
;
Oxazoles/pharmacology
;
Phosphorylation
;
Plant Roots/*cytology/metabolism
;
Protein Structure, Tertiary
;
Reactive Oxygen Species/*metabolism
;
Recombinant Fusion Proteins/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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