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  • 1
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    Reconstitution of T cell receptor zeta-mediated calcium mobilization in nonlymphoid cells (1993)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1993-08-13
    Description: T cell antigen receptor (TCR) activation involves interactions between receptor subunits and nonreceptor protein tyrosine kinases (PTKs). Early steps in signaling through the zeta chain of the TCR were examined in transfected COS-1 cells. Coexpression of the PTK p59fynT, but not p56lck, with zeta or with a homodimeric TCR beta-zeta fusion protein produced tyrosine phosphorylation of both zeta and phospholipase C (PLC)-gamma 1, as well as calcium ion mobilization in response to receptor cross-linking. CD45 coexpression enhanced these effects. No requirement for the PTKZAP-70 was observed. Thus, p59fynT may link zeta directly to the PLC-gamma 1 activation pathway.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hall, C G -- Sancho, J -- Terhorst, C -- AI 15066/AI/NIAID NIH HHS/ -- CA 01486/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1993 Aug 13;261(5123):915-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Immunology, Beth Israel Hospital, Harvard Medical School, Boston, MA 02115.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8346442" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, CD45/analysis ; Base Sequence ; Calcium/*metabolism ; Cell Line ; Cercopithecus aethiops ; Lymphocyte Specific Protein Tyrosine Kinase p56(lck) ; Membrane Proteins/*metabolism ; Molecular Sequence Data ; Phosphorylation ; Protein-Tyrosine Kinases/*metabolism/physiology ; Proto-Oncogene Proteins/*metabolism ; Proto-Oncogene Proteins c-fyn ; Receptors, Antigen, T-Cell/*metabolism ; Recombinant Fusion Proteins/metabolism ; Signal Transduction ; Transfection ; Type C Phospholipases/metabolism ; Tyrosine/metabolism ; ZAP-70 Protein-Tyrosine Kinase
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Internal structure and emplacement mechanism of composite plutons: evidence from Mt Kinabalu, Borneo (2017)
    Geological Society of London
    Details
    Publication Date: 2017-02-23
    Description: The internal structure and emplacement mechanisms of composite plutons are investigated using new field data from the composite Late Miocene granitic intrusion of Mt Kinabalu in northern Borneo. The pluton was emplaced in the upper to middle crust in the Late Miocene at the contact between the ultramafic basement and sedimentary cover rocks. Structural data indicate that emplacement occurred during regional NNW–SSE-oriented extension, challenging tectonic models that involve contemporaneous regional compression. The six major units forming the pluton were accommodated by upward flexure of the cover rocks with most magma pulses emplaced successively beneath their predecessors. However, the irregular 3D internal structure of the pluton also reflects preferential emplacement of successive units along the granite–country rock contact of previous units in preference to the basement–cover rock contact exploited by the initial units. This study highlights the complex emplacement mechanisms and internal structure of composite intrusions and assesses how they differ from models of tabular emplacement.
    Print ISSN: 0016-7649
    Topics: Geosciences
    Published by Geological Society of London
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  • 3
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    Internal structure and emplacement mechanism of composite plutons: evidence from Mt Kinabalu, Borneo (2017)
    Geological Society of London
    Details
    Publication Date: 2017-01-07
    Description: The internal structure and emplacement mechanisms of composite plutons are investigated using new field data from the composite Late Miocene granitic intrusion of Mt Kinabalu in northern Borneo. The pluton was emplaced in the upper to middle crust in the Late Miocene at the contact between the ultramafic basement and sedimentary cover rocks. Structural data indicate that emplacement occurred during regional NNW–SSE-oriented extension, challenging tectonic models that involve contemporaneous regional compression. The six major units forming the pluton were accommodated by upward flexure of the cover rocks with most magma pulses emplaced successively beneath their predecessors. However, the irregular 3D internal structure of the pluton also reflects preferential emplacement of successive units along the granite–country rock contact of previous units in preference to the basement–cover rock contact exploited by the initial units. This study highlights the complex emplacement mechanisms and internal structure of composite intrusions and assesses how they differ from models of tabular emplacement.
    Print ISSN: 0016-7649
    Topics: Geosciences
    Published by Geological Society of London
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