Publication Date:
1991-10-11
Description:
The neocortex is patterned in layers of neurons that are generated in an orderly sequence during development. This correlation between cell birthday and laminar fate prompted an examination of how neuronal phenotypes are determined in the developing cortex. At various times after labeling with [3H]thymidine, embryonic progenitor cells were transplanted into older host brains. The laminar fate of transplanted neurons correlates with the position of their progenitors in the cell cycle at the time of transplantation. Daughters of cells transplanted in S-phase migrate to layer 2/3, as do host neurons. Progenitors transplanted later in the cell cycle, however, produce daughters that are committed to their normal, deep-layer fates. Thus, environmental factors are important determinants of laminar fate, but embryonic progenitors undergo cyclical changes in their ability to respond to such cues.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McConnell, S K -- Kaznowski, C E -- EY08411/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 1991 Oct 11;254(5029):282-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Sciences, Stanford University, CA 94305.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1925583" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Brain Tissue Transplantation
;
Cell Cycle/*physiology
;
Cerebral Cortex/*embryology
;
Ferrets/embryology
;
G1 Phase/physiology
;
G2 Phase/physiology
;
Mitosis/physiology
;
Neurons/physiology
;
S Phase/physiology
;
Stem Cells/physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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