Publication Date:
1992-01-17
Description:
Three unrelated tumor cell lines derived from human malignant melanomas lack actin-binding protein (ABP), which cross-links actin filaments in vitro and connects these filaments to plasma membrane glycoproteins. The ABP-deficient cells have impaired locomotion and display circumferential blebbing of the plasma membrane. Expression of ABP in one of the lines after transfection restored translocational motility and reduced membrane blebbing. These findings establish that ABP functions to stabilize cortical actin in vivo and is required for efficient cell locomotion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cunningham, C C -- Gorlin, J B -- Kwiatkowski, D J -- Hartwig, J H -- Janmey, P A -- Byers, H R -- Stossel, T P -- AI 08051/AI/NIAID NIH HHS/ -- AR 38910/AR/NIAMS NIH HHS/ -- HL 19429/HL/NHLBI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1992 Jan 17;255(5042):325-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Divisions of Experimental Medicine, Brigham & Women's Hospital, Boston, MA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1549777" target="_blank"〉PubMed〈/a〉
Keywords:
Actins/physiology
;
Blotting, Southern
;
Cell Line
;
Cell Membrane/*physiology/ultrastructure
;
Cell Movement/*physiology
;
Humans
;
Melanoma
;
Membrane Glycoproteins/physiology
;
Microfilament Proteins/*physiology
;
Transfection
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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