Publication Date:
1998-07-24
Description:
The transcription factor NFAT (nuclear factor of activated T cells) controls the expression of many immunomodulatory proteins. African swine fever virus inhibits proinflammatory cytokine expression in infected macrophages, and a viral protein A238L was found to display the activity of the immunosuppressive drug cyclosporin A by inhibiting NFAT-regulated gene transcription in vivo. This it does by binding the catalytic subunit of calcineurin and inhibiting calcineurin phosphatase activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miskin, J E -- Abrams, C C -- Goatley, L C -- Dixon, L K -- New York, N.Y. -- Science. 1998 Jul 24;281(5376):562-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Animal Health, Pirbright Laboratory, Pirbright, Surrey, GU24 0NF, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9677199" target="_blank"〉PubMed〈/a〉
Keywords:
African Swine Fever Virus/*physiology
;
Amino Acid Sequence
;
Animals
;
Binding Sites
;
Calcineurin/metabolism
;
*Calcineurin Inhibitors
;
Cell Nucleus/metabolism
;
Cells, Cultured
;
Cercopithecus aethiops
;
Cyclosporine/pharmacology
;
DNA-Binding Proteins/genetics/*metabolism
;
Genes, Reporter
;
Macrophages, Alveolar/*virology
;
Molecular Sequence Data
;
NF-kappa B/metabolism
;
NFATC Transcription Factors
;
*Nuclear Proteins
;
Recombinant Proteins/metabolism
;
Swine
;
Transcription Factors/genetics/*metabolism
;
*Transcription, Genetic
;
Vero Cells
;
Viral Proteins/genetics/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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