Publication Date:
1991-11-22
Description:
A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4638169/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4638169/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Huang, D -- Swanson, E A -- Lin, C P -- Schuman, J S -- Stinson, W G -- Chang, W -- Hee, M R -- Flotte, T -- Gregory, K -- Puliafito, C A -- 1-R01-GM35459-06/GM/NIGMS NIH HHS/ -- R01 GM035459/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1991 Nov 22;254(5035):1178-81.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge 02139.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1957169" target="_blank"〉PubMed〈/a〉
Keywords:
Coronary Disease/diagnosis
;
Coronary Vessels/pathology
;
Humans
;
Image Processing, Computer-Assisted
;
In Vitro Techniques
;
Retinal Diseases/diagnosis/pathology
;
Tomography/*methods
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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